This study is looking at a condition called sepsis-associated acute kidney injury. Sepsis is a serious condition that happens when the body’s response to an infection causes damage to its own tissues and organs. Acute kidney injury means that the kidneys suddenly stop working properly and cannot filter waste from the blood as they should. This can happen when a person has sepsis. The study will test a medication called AZD4144, which is given through a vein as a solution for infusion. Some participants will receive AZD4144 while others will receive placebo. The purpose of the study is to evaluate the effect of AZD4144 on how well the kidneys can filter and clean the blood.
Participants in this study will be adults who are in the hospital with sepsis and have developed acute kidney injury. They must have been diagnosed with sepsis within seven days of being admitted to the hospital and must have developed kidney injury within a certain time after the sepsis diagnosis. Participants will need to be receiving medications to support their blood pressure because of the sepsis. The study medication must be given within a specific time window after the kidney injury is diagnosed.
During the study, doctors will measure how well the kidneys are working by checking various blood and urine tests. They will look at substances in the blood called creatinine and cystatin C, which show how well the kidneys are filtering. The study will also track whether participants need kidney replacement therapy, which is a treatment that does the work of the kidneys when they are not working properly. Other measurements will include how many days participants are alive without needing a breathing machine, how long they stay in the intensive care unit, and whether they need to return to the hospital after being discharged. The study will also measure the amount of AZD4144 in the blood to understand how the medication moves through the body.
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