This study is looking at schizophrenia that is in an acute phase, which means the symptoms have become worse recently. The study will test a medication called brexpiprazole that is given once a week. This medication comes in two forms: one is called brexpiprazole fumarate and another is called RXULTI. Some people in the study will receive placebo instead of the active medication. The purpose of this study is to see if brexpiprazole given once a week works better than placebo in treating the acute symptoms of schizophrenia.
People taking part in this study will have schizophrenia with symptoms that have gotten worse and will either be in the hospital or need to be in the hospital because of their condition. Their symptoms must have started getting worse within the past two months. Before joining the study, they must have been treated with other antipsychotic medications that worked for them in the past year. During the study, participants will be randomly assigned to receive either the brexpiprazole medication or placebo, and neither they nor their doctors will know which one they are getting. The treatment will be given by mouth as tablets.
The study will measure how much the symptoms change from the beginning of the study to week six. Doctors will use a standard rating scale to measure the symptoms of schizophrenia throughout the study period. The medication will be given once a week, and the study will track how well it works and whether it is safe for people with acute schizophrenia.
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