This study involves people with ovarian cancer, which is a type of cancer that develops in the ovaries or related tissues. The study will test different treatment combinations that include a medicine called mirvetuximab soravtansine, which is also known by its code name IMGN853. This medicine will be combined with other cancer drugs including carboplatin and bevacizumab. All of these medicines are given through a vein. The purpose of this study is to find out how safe these treatment combinations are and how well they work in treating ovarian cancer, and to determine the best dose of mirvetuximab soravtansine when it is used together with other medicines.
The study is divided into different parts called substudies. In one substudy, people will have a specific type of ovarian cancer that has certain characteristics, including being what doctors call high-grade serous cancer, which is a particular form of the disease. Some people in this substudy will have cancer that does not have certain genetic changes. In another substudy, people will have ovarian cancer that has come back after previous treatment with platinum-based chemotherapy, and their cancer must have returned more than six months after finishing that treatment. People in the study will receive different combinations of the medicines, and doctors will check how their cancer responds to treatment and watch for any side effects.
During the study, doctors will measure several things to understand how well the treatments work and how safe they are. They will count how many people have side effects of any severity, including serious ones, and how many people need to stop treatment because of side effects. They will pay special attention to eye problems, nerve problems, and lung problems that might occur. Doctors will also check whether the cancer shrinks or stops growing by using scans and blood tests. They will measure how long people live without their cancer getting worse and how long the cancer responds to treatment when it does shrink.



Belgium
Czechia
Denmark
France
Spain