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A study evaluating the effect of methylprednisolone compared to sodium chloride in patients with a heart attack

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What is this study about?

This study investigates the effects of a high-dose steroid treatment in individuals experiencing a ST-segment Elevation Myocardial Infarction, which is a serious type of heart attack. The research aims to evaluate whether giving a large dose of the medication methylprednisolone through an intravenous infusion, which means the medicine is delivered directly into a vein, can affect the rate of death from any cause in these patients. Participants will receive either the active medication or a placebo consisting of sodium chloride.

Who Can Join the Study?

  • You must be 18 years of age or older, which includes women who are able to have children.
  • You must have experienced a sudden onset of chest pain that started less than 24 hours ago.
  • You must have been diagnosed with STEMI, which is a serious type of heart attack where a specific pattern of electrical activity is seen on an electrocardiogram (a test that records the heart’s electrical signals).
  • The electrocardiogram must show specific patterns of ST-segment elevation, which refers to a specific part of the heart’s electrical wave being higher than normal, indicating a blockage in a heart artery.
  • The patterns may also include a new left bundle branch block, which is a change in the electrical conduction system of the heart that affects how the heart beats.
  • The diagnosis may also be based on specific patterns of ST depression, where the electrical wave is lower than normal, suggesting certain types of heart muscle damage or blockages in major arteries.

Who Cannot Join the Study?

  • You are suspected of having a type of heart attack other than Type I acute myocardial infarction, which is a heart attack caused by a sudden blockage in one of the heart’s arteries.
  • You experienced a cardiac arrest, which is when the heart suddenly stops beating, outside of a hospital setting.
  • You have a known allergy, which is an extreme reaction by your immune system, to glucocorticoids, which are a type of steroid medication used to reduce inflammation.

Where you can join this trial?

Verified and Recommended Sites

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Verified Sites

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Other Sites

Site Name City Country Status
Odense University Hospital Odense Denmark
Aalborg University Hospital Aalborg Denmark
Rigshospitalet Copenhagen Denmark
Ashyfu Uybohmxost Hnvcslul Aarhus Denmark

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Denmark Denmark
Recruiting
15.04.2026

Trial locations

Investigated drugs:

Methylprednisolone is a type of steroid medication used to reduce inflammation and suppress the immune system. In this study, it is being tested to see if giving a high dose before reaching the hospital can improve outcomes for patients experiencing a specific type of heart attack.

ST-segment Elevation Myocardial Infarction – This condition occurs when a coronary artery becomes completely blocked, preventing blood flow to a part of the heart muscle. This lack of oxygen causes damage to the heart tissue. The condition typically develops suddenly and involves specific changes in the heart’s electrical activity. As the blockage persists, the affected muscle cells may become injured or die.

Trial ID:
2025-524320-21-00
Trial Phase:
Therapeutic confirmatory (Phase III)

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