Wave Life Sciences Ireland Limited

Alpha-1 antitrypsin deficiency

Research activity includes Pi*ZZ alpha-1 antitrypsin deficiency, with attention to the clinical needs of adults affected by this inherited liver and lung disease. The funded studies reflect interest in disease-modifying approaches for a rare genetic disorder associated with protein misfolding and tissue injury.

  • AATD
  • Pi*ZZ genotype
  • Inherited protein deficiency
  • Hepatic and pulmonary disease

Clinical work in this area is centered on therapeutic development for a rare disease population with unmet need in both respiratory and hepatic care.

Overweight and obesity

The sponsor also supports research in adults living with overweight or obesity, focusing on a common metabolic condition linked to cardiometabolic risk and long-term weight management challenges.

  • Obesity
  • Weight management
  • Metabolic health
  • Adult population

This area of interest aligns with therapeutic development for chronic conditions where treatment options are closely tied to improving metabolic outcomes and body-weight regulation.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study on the Safety and Tolerability of WVE-006 for Patients with Alpha-1 Antitrypsin Deficiency (AATD) Pi*ZZ

    Not recruiting

    1 1
    Investigated drugs:
    Finland Germany