HIV-1 Treatment in Antiretroviral-Naïve Adults
Clinical research includes oral and long-acting antiretroviral therapy options for adults newly diagnosed with HIV, with attention to viral suppression, treatment initiation, and regimen selection in people who have not previously received therapy.
- Oral once-daily treatment regimens
- Long-acting injectable ART
- Viral suppression in treatment-naïve adults
Studies also examine comparative effectiveness between simplified dual-drug and standard multi-drug approaches in initial HIV-1 management.
Long-Acting and Switch-Based Maintenance Therapy
Research activity extends to maintaining virologic suppression after switching from established oral regimens to long-acting combinations, including injectable approaches for adults already living with controlled HIV infection.
- Switch strategies after suppression
- Two-monthly injectable combinations
- Durability of treatment response
This area includes assessment of treatment choice and preference in adults considering oral versus injectable maintenance options.
Heavily Treatment-Experienced and Drug-Resistant HIV
The sponsor supports studies in adults with limited treatment options due to multidrug-resistant HIV-1 or prior antiretroviral exposure, including settings where current regimens are failing or no longer fully effective.
- Drug-resistant HIV-1
- Heavily treatment-experienced populations
- Salvage and rescue treatment strategies
Research in this domain focuses on restoring antiviral control in people with complex treatment histories.
Novel Antiviral Agents and Regimen Innovation
Clinical work includes evaluation of new HIV therapies such as attachment inhibitors, capsid-targeting agents, and other oral compounds designed to expand treatment choices for both untreated and treatment-experienced adults.
- Attachment inhibitor-based regimens
- Capsid-directed antiviral candidates
- Oral regimen development
These studies are directed toward improving antiviral activity and broadening options for HIV-1 management.
Reservoir and Immune-Based HIV Research
Additional research interest includes the viral reservoir and the use of broadly neutralizing antibodies alongside integrase inhibitor-based therapy in adults living with HIV.
- Viral reservoir modulation
- Broadly neutralizing antibodies
- Combination approaches with integrase-based therapy
This area reflects interest in deeper virologic control beyond routine suppression.
