Maternal, Neonatal, and Paediatric Neurology
Research activity includes neonatal brain perfusion, cerebral elasticity, and early-life brain injury in newborns with hypoxic-ischemic, infectious, and ischemic conditions. The sponsor also studies maternal immunisation and the longer-term immune effects of pertussis vaccination in children.
- Neonatal cerebral imaging
- Brain perfusion assessment
- Maternal and childhood pertussis immunity
These studies reflect interest in early diagnostic evaluation of the developing brain and in immune protection during pregnancy and early childhood.
Multiple Sclerosis and Central Nervous System Inflammation
Clinical research focuses on multiple sclerosis, with attention to microglial activation, white matter changes, and inflammatory activity in the central nervous system. The portfolio also includes evaluation of treatments used in progressive MS.
- Microglial imaging
- Neuroinflammation
- Progressive multiple sclerosis
The sponsor’s neurological work is centered on biomarkers and immune-mediated mechanisms relevant to chronic demyelinating disease.
Gastroenterology and Inflammatory Bowel Disease
Trials address ulcerative colitis and Crohn’s disease, with particular interest in fecal microbiota transplantation alongside biologic therapy. The research also explores intestinal microbial changes in relation to treatment response and safety.
- Ulcerative colitis
- Crohn’s disease
- Gut microbiota modulation
This area combines immune-mediated bowel disease with microbiome-focused therapeutic strategies.
Oncology and Pelvic Lymph Node Imaging
Oncology-related studies involve rectal cancer, especially the assessment of mesorectal lymph node metastases and nodal staging using advanced imaging approaches. The focus is on improving detection of pelvic lymph node involvement in newly diagnosed disease.
- Rectal cancer
- Mesorectal lymph node metastases
- Pelvic staging imaging
Imaging-based cancer research is a distinct part of the sponsor’s clinical portfolio, linking diagnostic refinement with colorectal oncology.
Vaccinology, Healthy Volunteers, and Clinical Pharmacology
Additional studies include diphtheria, tetanus, and pertussis immunity in health care workers, together with investigations in healthy volunteers and phase I clinical research. The unit also supports work in clinical pharmacology and drug-related measurement studies.
- dTap booster vaccination
- Healthy volunteer research
- Clinical pharmacology
This section of activity spans vaccine immunology and early human research in a hospital-based pharmacology setting.
