Upstream Bio Inc.

Chronic Rhinosinusitis with Nasal Polyps

Clinical research in chronic rhinosinusitis with nasal polyps centers on improving control of nasal polyps and related upper-airway inflammation, with attention to symptom burden and endoscopic outcomes.

  • Endoscopic nasal polyp score
  • Nasal corticosteroid background therapy
  • Upper airway inflammation

The sponsor is active in respiratory and inflammatory disease research with a focus on conditions affecting the nasal and sinus passages.

Severe Asthma

Studies in severe asthma examine disease control, asthma exacerbations, and long-term treatment tolerability in adults with persistent airway inflammation.

  • Asthma exacerbation prevention
  • Long-term safety
  • Adult severe asthma

Research activity in this area reflects interest in difficult-to-control airway disease and outcomes relevant to ongoing respiratory management.

Chronic Obstructive Pulmonary Disease

Clinical trials in chronic obstructive pulmonary disease focus on reducing COPD exacerbations and improving overall disease control in adults with moderate-to-severe respiratory impairment.

  • COPD exacerbations
  • Moderate-to-severe COPD
  • Airflow limitation

This area adds to the sponsor’s portfolio in chronic inflammatory and obstructive lung disorders.

Type 2 Inflammatory Airway Disease

The sponsor’s pipeline spans overlapping type 2 inflammatory airway conditions, including upper and lower respiratory tract disorders characterized by eosinophilic inflammation and recurrent symptoms.

  • Eosinophilic airway inflammation
  • Respiratory immunology
  • Chronic inflammatory airway disorders

This research landscape connects asthma, COPD, and nasal polyposis within a shared therapeutic domain.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study of Verekitug to improve symptoms in patients with moderate to severe chronic obstructive pulmonary disease (COPD)

    Not recruiting

    Investigated diseases:
    Bulgaria Czechia Germany Hungary Ireland Latvia +5
  • Long-term safety and effectiveness study of verekitug injections in adults with severe asthma who completed the VALIANT trial

    Not recruiting

    Bulgaria Czechia Germany Italy Poland Spain
  • Study on the Effects of Verekitug (UPB-101) for Patients with Chronic Rhinosinusitis with Nasal Polyps Using Nasal Corticosteroids

    Not recruiting

    Czechia Germany Poland Spain
  • Study on the Effects of Verekitug (UPB-101) for Adults with Severe Asthma

    Not recruiting

    Investigated diseases:
    Bulgaria Czechia Germany Italy Poland Spain