Oncology and Hematologic Malignancies
Universitair Medisch Centrum Utrecht is active in studies across solid tumors and blood cancers, with interest in colorectal cancer, head and neck squamous cell carcinoma, endometrial cancer, liver metastases, acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma. Its trial portfolio also includes rare and difficult-to-treat cancers such as parotid gland carcinoma, diffuse midline glioma, and pheochromocytoma.
- metastatic colorectal cancer
- oral cancer
- colorectal liver metastases
- H3K27-altered pontine diffuse midline glioma
- acute myeloid leukemia
Research interests extend to sentinel lymph node mapping, imaging-guided treatment selection, and locoregional approaches for advanced malignancy.
Immune-Mediated, Rheumatologic, and Rare Inflammatory Disease
The sponsor supports trials in systemic sclerosis, idiopathic inflammatory myopathies, IgG4-related disease, primary Sjögren’s syndrome, psoriatic arthritis, Behçet’s disease, and Still’s disease. Additional work includes immune deficiency and antibody-associated disorders such as common variable immunodeficiency, IgA deficiency, and IgM monoclonal gammopathy of unknown significance with anti-MAG polyneuropathy.
- systemic sclerosis
- primary Sjögren’s syndrome
- idiopathic inflammatory myopathies
- psoriatic arthritis
- immune deficiency disorders
Its portfolio also covers diffuse cutaneous systemic sclerosis, pseudoxanthoma elasticum, and other rare immune-mediated conditions with vascular, musculoskeletal, or neurologic involvement.
Neurology, Neurodevelopment, and Brain Injury
Clinical research includes refractory epilepsy, Fahr’s disease, Fahr’s syndrome, perinatal arterial ischemic stroke, and neonatal brain injury associated with critical congenital heart disease. The sponsor also funds studies in diffuse midline glioma and conditions involving cognitive and neurologic decline.
- refractory epilepsy
- perinatal arterial ischemic stroke
- neonatal brain injury
- Fahr’s disease
- diffuse midline glioma
Work in this area also spans brain protection in newborns, neurologic outcomes after stroke, and disorders affecting cognition, movement, and seizure control.
Cardiovascular, Vascular, and Metabolic Disorders
Trial activity includes peripheral arterial disease, carotid artery stenosis, arterial calcification, and vascular complications of systemic sclerosis. The sponsor also studies type 2 diabetes mellitus, congenital haemophilia A, and atherosclerotic disease with interest in bleeding prevention, vascular imaging, and endothelial injury.
- peripheral arterial disease
- carotid artery stenosis
- type 2 diabetes mellitus
- congenital haemophilia A
- arterial calcification
Its research also addresses myocardial and vascular protection, limb ischemia, and complications linked to chronic metabolic and circulatory disease.
Infectious, Respiratory, Psychiatric, and Reproductive Health
The sponsor funds studies in COVID-19, post-acute sequelae of SARS-CoV-2 infection, monkeypox, Staphylococcus aureus bacteremia, and respiratory tract infection. It also supports research in schizophrenia, major depressive disorder, bipolar depression, anxiety disorders, and post-traumatic stress disorder, alongside reproductive and fertility care such as unexplained subfertility and intra-uterine insemination.
- COVID-19
- post-acute sequelae of SARS-CoV-2 infection
- schizophrenia
- major depressive disorder
- unexplained subfertility
Additional interests include acute respiratory infections, viral clearance, mood disorders, and treatment-resistant psychiatric illness.
