Kidney disease and transplantation
Research activity is strongly centered on chronic kidney disease, albuminuria, autosomal dominant polycystic kidney disease, and kidney failure, with additional work in kidney transplantation and lung transplantation.
- Renal function preservation
- Proteinuria and albuminuria
- Polycystic kidney disease
- Transplant immunology
The portfolio also includes studies in primary aldosteronism and methods related to glomerular filtration rate assessment.
Oncology and haematologic malignancies
The sponsor funds research across multiple cancer types, including diffuse large B-cell lymphoma, non-small cell lung cancer, head and neck squamous cell carcinoma, colorectal cancer, cervical cancer, ovarian cancer, and hepatocellular carcinoma.
- Lymphoma and multiple myeloma
- Solid tumours and metastatic disease
- Head and neck cancer
- Cell therapy and immunotherapy
Its oncology work also includes molecular imaging, fluorescence-guided surgery, and studies in cancer biomarkers and tumour targeting.
Inflammatory, autoimmune, and gastrointestinal disease
Important therapeutic areas include inflammatory bowel disease, Crohn’s disease, ulcerative colitis, rheumatoid arthritis, psoriasis, giant cell arteritis, polymyalgia rheumatica, and Sjögren’s disease.
- Immune-mediated inflammation
- Rheumatologic disease
- Gastrointestinal inflammation
- Dermatologic immune disorders
Additional work addresses eosinophilic granulomatosis with polyangiitis, hand eczema, and immune-related tissue imaging.
Neurology, psychiatry, and neurodegeneration
Clinical research spans depression, psychosis, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease, alongside other neurodegenerative disorders.
- Treatment-resistant depression
- First-episode psychosis
- Movement disorders
- Cognitive impairment
The portfolio also includes studies in electroconvulsive therapy, esketamine, and biomarker-based brain imaging.
Cardiometabolic, respiratory, and critical care
Further research covers heart failure, cardiovascular disease, type 1 diabetes, type 2 diabetes, chronic obstructive pulmonary disease, ECMO, and acute respiratory distress syndrome.
- Cardiorenal disease
- Diabetes-related kidney injury
- Respiratory failure
- Extracorporeal life support
Additional interests include post-acute sequelae of COVID-19, long COVID, ATTR cardiomyopathy, and metabolic inflammation.
