Haematologic Malignancies and Cellular Immunotherapy
Research activity includes diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, follicular lymphoma, and high-grade B-cell lymphoma, with a strong focus on advanced treatment strategies for relapsed or refractory disease. The portfolio also extends to CAR T-cell therapy and other immune-based approaches in aggressive lymphoid cancers.
- Diffuse large B-cell lymphoma (DLBCL)
- Primary mediastinal large B-cell lymphoma (PMBCL)
- Follicular lymphoma grade 3B
- High-grade B-cell lymphoma (HGBL)
Investigations in this area also address treatment resistance and response assessment in relapsed/refractory lymphoma.
Solid Tumours in Paediatric and Adult Oncology
Clinical research spans neuroblastoma, osteosarcoma, soft-tissue sarcoma, and breast cancer, alongside advanced disease settings such as metastatic castration-resistant prostate cancer and advanced breast cancer. The sponsor also supports work in ductal carcinoma in situ and high-risk post-surgical prostate cancer.
- Neuroblastoma
- Osteosarcoma
- Soft-tissue sarcoma
- Breast cancer and ductal carcinoma in situ
- Metastatic castration-resistant prostate cancer
These studies reflect interest in both paediatric solid tumours and advanced genitourinary and breast malignancies.
Brain Tumours and Neuro-Oncology
A major area of interest is neuro-oncology, including high-grade glioma, recurrent glioblastoma, and other brain tumours in children, adolescents, and adults. The research portfolio includes imaging-guided and fluorescence-assisted approaches in central nervous system tumours.
- High-grade glioma
- Recurrent glioblastoma
- Paediatric intra-axial brain tumours
- Other brain tumours
Work in this field is closely linked to surgical oncology and tumour visualisation in central nervous system cancers.
Renal Injury, Critical Illness, and Metabolic Disorders
The sponsor also funds studies in acute kidney injury, metabolic acidosis, and critical illness, with attention to kidney-related complications in surgical and intensive care settings. This includes research relevant to perioperative nephrology and critical care medicine.
- Acute kidney injury
- Metabolic acidosis
- Critical illness
- Kidney-related complications after surgery
These areas highlight interest in organ protection and metabolic management in acutely ill patients.
Imaging, Fluorescence-Guided Surgery, and Tumour Detection
Several trials focus on molecular imaging, fluorescence-guided surgery, and detection of occult disease in oncology. Research includes PET/MRI applications in breast lesions, as well as visualisation techniques for tumour resection in brain cancer.
- FAPI-PET/MRI
- Fluorescence-guided resection
- Occult invasive cancer detection
- Radiodynamic and sonodynamic therapy
This work connects diagnostic imaging with oncologic intervention across breast and neuro-oncology settings.
