Cardiovascular medicine
Research activity includes acute myocardial infarction in patients with ST-elevation myocardial infarction and multivessel disease, with attention to coronary microcirculation and microvascular dysfunction.
- Myocardial infarction
- Coronary microcirculation
- Microvascular dysfunction
The cardiovascular portfolio also reflects interest in inflammatory biomarkers and endothelial function in cardiometabolic disease.
Neurogenetic disorders
Clinical research extends to Friedreich’s ataxia, with focus on FXN transcription and frataxin protein biology.
- Friedreich’s ataxia
- FXN transcription
- Frataxin protein
This area places emphasis on molecular mechanisms relevant to mitochondrial dysfunction and inherited neurologic disease.
Diabetes and metabolic disease
Trials in type 2 diabetes mellitus examine cardiometabolic risk, including patients without established atherosclerotic cardiovascular disease but with elevated SCORE2-Diabetes risk.
- Type 2 diabetes mellitus
- Cardiometabolic risk
- Atherosclerotic cardiovascular disease
Research interest also includes metabolic inflammation and biomarker changes linked to diabetes-related vascular risk.
Inflammation and vascular biomarkers
Across its studies, the sponsor is engaged in work on inflammatory biomarkers, endothelial biomarkers, and vascular injury in both cardiac and metabolic settings.
- Inflammatory biomarkers
- Endothelial biomarkers
- Vascular injury
This includes interest in mechanisms that connect cardiovascular disease with diabetes and systemic inflammation.
