Neuro-oncology and brain tumours
Clinical research in glioblastoma focuses on treatment strategies for IDH-wildtype glioblastoma and imaging-based assessment of tumour control in the post-surgical setting.
- High-grade glioma
- Glioblastoma response evaluation
- Radiographic disease assessment
The sponsor’s work in this area centres on therapeutic approaches used alongside established neuro-oncology care.
Paediatric and adolescent haematology
Research includes acute lymphoblastic leukemia across children, adolescents, and young adults, with attention to Philadelphia chromosome-positive disease and ABL-class Philadelphia chromosome-like B-cell acute lymphoblastic leukemia.
- Ph+ B-cell acute lymphoblastic leukemia
- ABL-class Ph-like B-ALL
- Event-free survival
Trials in this field address intensive leukemia treatment pathways and targeted therapy combinations in younger populations.
Lymphoma and targeted oncology
The sponsor supports studies in anaplastic large cell lymphoma with ALK expression, including disease that has become resistant to prior ALK inhibitor treatment.
- ALK-positive lymphoma
- Refractory lymphoma
- Targeted cancer therapy
This area reflects a strong interest in precision treatment options for relapsed or treatment-resistant lymphoid malignancies.
Hepatology and cholestatic liver disease
Clinical activity also includes primary sclerosing cholangitis, with research interest in liver inflammation, cholestasis, and biochemical markers of biliary disease.
- Primary sclerosing cholangitis
- Alkaline phosphatase
- Biliary tract disease
These studies relate to management of chronic hepatobiliary disorders and their clinical monitoring.
Neurology, geriatrics, and cognitive health
Another research focus concerns cognitive profiles in older adults, especially in the context of perioperative delirium and recovery after hip fracture.
- Cognitive decline
- Delirium
- Geriatric rehabilitation
Work in this domain links brain function with acute hospital care and postoperative neurological outcomes.
