Hematologic Malignancies
Clinical research in acute myeloid leukemia, including newly diagnosed AML with NPM1 mutation and relapsed or refractory acute leukemias, with attention to disease control, remission outcomes, and treatment response in genetically defined subgroups.
- Acute Myeloid Leukemia
- Relapsed/Refractory Leukemias
- NPM1-mutated AML
- KMT2A/MLL
- NUP98
Interest extends to measurable residual disease clearance, complete remission, and event-free survival in combination with intensive chemotherapy.
Chronic Graft Versus Host Disease
Studies in cGVHD focus on patients whose disease persists after multiple prior therapies, with outcomes centered on overall response and symptom burden in a difficult-to-treat transplant-related condition.
- Chronic graft versus host disease
- Post-transplant complications
- Refractory immune-mediated disease
- Overall response rate
The therapeutic emphasis includes immune dysregulation and treatment options for patients who have failed prior lines of therapy.
Pulmonary Fibrosis
Research in idiopathic pulmonary fibrosis addresses lung function decline and respiratory impairment, reflecting interest in chronic fibrotic lung disease and its impact on breathing capacity over time.
- Idiopathic pulmonary fibrosis
- Lung function
- Fibrotic interstitial lung disease
- Respiratory decline
These studies concentrate on pulmonary outcomes relevant to progressive fibrosis and functional limitation.
Targeted Oncology and Combination Therapy
The sponsor’s oncology program includes revumenib and SNDX-5613 in combination settings, with research spanning leukemia subtypes defined by epigenetic and molecular alterations.
- Combination with intensive chemotherapy
- Epigenetic dysregulation
- Molecularly defined leukemia
- Pharmacokinetics
- Safety and tolerability
Key areas include treatment development for KMT2A/MLL-altered leukemia and other genomically selected acute leukemia populations.
Clinical Development Across Multiple Sites
The research portfolio spans multicenter studies across North America and additional international settings, supporting trials in both oncology and non-oncology disease areas.
- Multicenter clinical research
- International trial activity
- Oncology and fibrosis programs
- Recruiting studies
Current activity includes studies in hematologic cancer, transplant-related disease, and interstitial lung disease.
