Paediatric Acute Lymphoblastic Leukaemia
Clinical research in acute lymphoblastic leukaemia focuses on allogeneic stem cell transplantation for children and adolescents, with attention to donor matching, post-transplant outcomes, and survival after haematopoietic stem cell transplantation.
- Allogeneic stem cell transplantation
- HLA-matched and mismatched donor strategies
- Conditioning regimens
- Overall survival
- Event-free survival
Interest extends to transplant settings using sibling, unrelated, cord blood, and haplo-identical donors in paediatric leukaemia.
Langerhans Cell Histiocytosis
Research in Langerhans cell histiocytosis addresses both single-system and multisystem disease, with emphasis on preventing reactivations, limiting late sequelae, and improving disease control in children and adolescents.
- Multisystem LCH
- Single-system LCH
- Risk organ involvement
- Reactivation prevention
- Late sequelae
The therapeutic focus includes patients with CNS-risk lesions, multifocal bone lesions, and non-risk organ disease.
Transplantation and Donor Compatibility
Another active area is stem cell transplantation in paediatric malignancy, including comparisons across HLA-identical sibling donors, matched donors, and mismatched donor sources.
- HLA matching
- Sibling donor transplantation
- Unrelated donor transplantation
- Cord blood transplantation
- Haplo-identical family donor transplantation
These studies also examine adverse events of special interest and transplant-related outcomes in different donor groups.
Paediatric Haematology and Oncology
The sponsor’s portfolio sits within paediatric haematology and oncology, with a particular emphasis on treatment pathways for childhood blood cancers and histiocytic disorders.
- Childhood blood cancers
- Transplant oncology
- Treatment continuation strategies
- Disease control in relapsed settings
- Long-term outcome reduction
Research activity is concentrated in Vienna with collaboration across multiple international sites in Europe and beyond.
