Urothelial and Bladder Cancer
Clinical research in urothelial carcinoma and bladder cancer includes locally advanced, metastatic, and non-muscle invasive disease, with additional attention to HER2-expressing and muscle invasive bladder cancer.
- Urothelial carcinoma
- Bladder cancer
- Non-muscle invasive bladder cancer
- Muscle invasive bladder cancer
- HER2-positive urothelial cancer
Research activity also extends to metastatic urothelial cancer and perioperative treatment settings.
Breast and Gastrointestinal Malignancies
Trials address breast cancer, including HER2-positive, HER2-low, hormone receptor-positive, and triple-negative breast cancer, alongside gastric cancer, gastroesophageal junction carcinoma, colorectal cancer, and pancreatic cancer.
- HER2-positive breast cancer
- Triple-negative breast cancer
- Gastric cancer
- Gastroesophageal junction carcinoma
- Colorectal cancer
Additional interest includes HER2-altered solid tumors and advanced gastrointestinal cancers.
Gynecologic and Head and Neck Cancers
Research spans cervical cancer, ovarian cancer, endometrial cancer, fallopian tube cancer, and primary peritoneal cancer, with parallel work in head and neck cancer and head and neck squamous cell carcinoma.
- Cervical cancer
- Ovarian cancer
- Endometrial cancer
- Head and neck squamous cell carcinoma
- Esophageal squamous cell carcinoma
The portfolio also includes recurrent and metastatic gynecologic malignancies and squamous cell carcinomas of the upper aerodigestive tract.
Lymphomas and Other Hematologic Malignancies
Clinical studies cover classical Hodgkin lymphoma, diffuse large B-cell lymphoma, peripheral T-cell lymphoma, anaplastic large-cell lymphoma, cutaneous T-cell lymphoma, and myeloid malignancies.
- Classical Hodgkin lymphoma
- Diffuse large B-cell lymphoma
- Peripheral T-cell lymphoma
- Cutaneous T-cell lymphoma
- Acute myeloid leukaemia
There is also activity in relapsed or refractory lymphoid disease and CD30-expressing hematologic cancers.
Solid Tumors and Targeted Therapeutic Areas
Broader oncology research includes non-small cell lung cancer, small cell lung cancer, melanoma, mesothelioma, cholangiocarcinoma, adenoid cystic carcinoma, and germ cell tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- Cutaneous melanoma
- Mesothelioma
- Cholangiocarcinoma
Much of this work focuses on HER2 alterations, antibody-drug conjugate targets, and advanced metastatic solid tumors.
