Cardiovascular and Critical Care
Research activity includes acute heart failure, pulmonary congestion, fluid overload, and heart failure with reduced ejection fraction, alongside studies in atrial fibrillation, deep vein thrombosis, pulmonary embolism, coronary artery disease, ischemic heart disease, chronic coronary syndrome, and coronary microvascular disease.
- Diuretic therapy and vasodilation
- Anticoagulation and thromboembolic disease
- Coronary inflammation and microvascular dysfunction
Additional work extends to intensive care fluid management and perioperative blood loss in surgical settings.
Oncology and Melanoma
The sponsor funds research in advanced melanoma, metastatic melanoma, uveal melanoma, basal cell carcinoma, angiosarcoma, undifferentiated pleomorphic sarcoma, pancreatic cancer, rectal cancer, and metastatic non-clear cell renal cell carcinoma.
- Immunotherapy in melanoma
- Targeted treatment in pancreatic malignancy
- Skin cancer and soft tissue sarcoma
Investigations also include brain metastases and treatment-resistant disease settings requiring combined oncologic strategies.
Psychiatry and Substance Use
Clinical studies address bipolar disorder, depression, schizophrenia, non-affective psychosis, acute agitation, and cannabis use disorder, as well as alcohol use disorder and related dependence conditions.
- Mood stabilization in bipolar illness
- Psychosis and antipsychotic response
- Addiction treatment for alcohol and cannabis use
Work in this area also includes cognitive side effects, depressive symptom control, and emergency management of behavioral disturbance.
Metabolic, Endocrine, and Musculoskeletal Disorders
Studies cover type 2 diabetes, obesity, overweight, early puberty, menopause, adynamic bone disorder, osteoarthritis, hip fracture, distal radius fracture, and diabetic foot ulcer or Charcot neuroarthropathy.
- Bone metabolism and pubertal development
- Diabetes-related foot disease
- Joint pain and fracture recovery
Research also includes male infertility and semen quality, linking endocrine and reproductive health with metabolic disease.
Respiratory, Allergic, and Infectious Disease
Ongoing trials involve chronic obstructive pulmonary disease, childhood asthma, eosinophilic airway inflammation, chronic spontaneous urticaria, chronic hand eczema, MRSA carriage, and Gram-negative bacteremia.
- Airway inflammation and asthma-like symptoms
- Skin allergy and urticaria
- Antimicrobial treatment and infection control
Further activity includes postoperative infection prevention and treatment of esophageal food impaction and other acute hospital presentations.
