Epilepsy and Seizure Disorders
Clinical research focuses on adult epilepsy, including focal epilepsy and primary generalized tonic-clonic seizures, with attention to seizure control and treatment response in people using background anti-seizure medications.
- Focal onset seizures
- Primary generalized tonic-clonic seizures
- Seizure frequency
The sponsor also studies photoparoxysmal electroencephalogram response in epilepsy, reflecting interest in seizure-related neurophysiological markers.
Developmental and Epileptic Encephalopathies
Research extends to severe pediatric developmental and epileptic encephalopathies, with a particular focus on SCN2A and SCN8A-related disease.
- SCN2A-DEE
- SCN8A-DEE
- Early-onset epileptic syndromes
These studies address countable motor seizures and broader seizure burden in children with genetically defined epileptic disorders.
Ion Channel-Related Neurology
The sponsor has a clear therapeutic interest in voltage-gated sodium channel biology, especially conditions linked to SCN2A and SCN8A dysfunction.
- SCN2A developmental and epileptic encephalopathy
- Sodium channel dysfunction
- Neurogenetic epilepsy
This area includes research in both adult and pediatric populations with inherited seizure disorders.
Therapeutic Development in Seizure Control
Current trials explore investigational treatments for focal seizures, focal onset seizures, and tonic-clonic seizures, alongside treatment assessment in participants receiving existing anti-seizure therapy.
- Adjunctive seizure treatment
- Adult seizure management
- Pediatric seizure disorders
Research activity also includes evaluation of drug-drug interaction potential in support of neurological treatment development.
