Narodni Ustav Dusevniho Zdravi

Psychiatric Disorders

The sponsor’s clinical research includes depressive disorder with a focus on difficult-to-treat presentations, particularly pharmaco-resistant depression and severe depressive symptoms requiring novel therapeutic options.

  • Depression
  • Treatment-resistant mood disorders
  • Rapid antidepressant response

Its psychiatric portfolio centers on interventions aimed at reducing depressive symptom burden in patients whose illness has not responded adequately to standard antidepressant care.

Psychedelic-based Therapies

Research activity includes the therapeutic use of psilocybin in mood disorders, with attention to its role in fast-acting antidepressant treatment and symptom relief in refractory depression.

  • Psilocybin therapy
  • Rapid-acting antidepressants
  • Novel psychopharmacology

The sponsor is engaged in clinical work exploring psychedelic compounds as potential options for patients with limited response to conventional psychiatric medicines.

A distinct area of interest is depression comorbid with cancer, addressing psychological distress in the context of oncological disease and the mental health needs associated with cancer care.

  • Cancer-related depression
  • Psychiatric support in oncology
  • Comorbid mental illness

This work reflects a therapeutic focus on depressive symptoms arising alongside cancer treatment and disease burden.

Comparative Antidepressant Treatment

The sponsor’s studies also examine ketamine and midazolam in relation to antidepressant effects, with interest in distinguishing active rapid-response treatments from control comparators in severe depression.

  • Ketamine
  • Midazolam
  • Acute mood symptom reduction

These investigations are positioned within the broader field of fast-onset interventions for patients with major depressive symptoms and limited therapeutic options.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Study on Psilocybin, Ketamine, and Midazolam for Treating Depression in Cancer Patients

    Recruiting

    2 1 1
    Investigated diseases:
    Czechia
  • Study on Psilocybin, Ketamine, and Midazolam for Patients with Treatment-Resistant Depression

    Not recruiting

    2 1 1
    Investigated diseases:
    Czechia