Oncology and solid tumor research
Clinical activity spans advanced solid tumors, non-small cell lung cancer, lung cancer, gastric cancer, pancreatic ductal adenocarcinoma, epithelial ovarian cancer, and colorectal cancer, with additional interest in metastatic and locally advanced unresectable tumors.
- METex14 skipping alterations and MET amplification
- EGFR-mutated lung cancer
- CEACAM5-targeted solid tumor programs
- DNA damage response and topoisomerase 1-based combinations
Research also includes head and neck squamous cell carcinoma, reflecting a broad oncology portfolio across thoracic, gastrointestinal, and upper aerodigestive malignancies.
Autoimmune disease and rheumatology
Trials address systemic lupus erythematosus, cutaneous lupus erythematosus, subacute cutaneous lupus, dermatomyositis, and polymyositis, with a focus on inflammatory disease activity and symptom control.
- Lupus spectrum disorders
- Inflammatory myopathies
- Cutaneous autoimmune manifestations
- Disease activity and tolerability in immune-mediated disease
The portfolio links systemic and skin-focused autoimmune conditions with broader immune modulation research.
Neuromuscular and rare immune-mediated disorders
Investigations include generalized myasthenia gravis, alongside autoimmune conditions that affect muscle strength and neuromuscular function.
- Generalized myasthenia gravis
- Autoimmune neuromuscular disease
- Muscle weakness and functional impairment
This area extends the sponsor’s interest in immune-mediated disorders beyond dermatologic and systemic rheumatology indications.
Head and neck and radiotherapy-related cancer care
Studies involve locally advanced squamous cell carcinoma of the head and neck and resected head and neck squamous cell carcinoma, with attention to treatment settings that include radiotherapy and postoperative disease control.
- Head and neck squamous cell carcinoma
- Resected and locally advanced disease
- Radiation-based cancer treatment
These programs connect local-regional cancer management with systemic anti-cancer strategies.
Healthy volunteer and special population studies
Research also includes healthy volunteers, renal impairment cohorts, and reproductive health-related studies such as infertility and pituitary-suppressed female participants.
- Renal impairment
- Healthy participant studies
- Female reproductive endocrinology
- Pharmacokinetics in special populations
These trials support development across both disease-focused and population-specific clinical settings.
