Nephrology and Kidney Transplantation
Research activity includes chronic kidney disease, end stage renal failure, hemodialysis, peritoneal dialysis, kidney transplantation, post-kidney transplantation, and late antibody mediated renal transplant rejection. The portfolio also extends to living donor kidney transplant care and regulatory T cell-based immune modulation in transplant settings.
- Kidney failure
- Renal transplant rejection
- Dialysis-related care
- Transplant immunology
Additional work covers immune-guided treatment strategies and post-transplant management in patients with complex renal disease.
Cardiovascular, Critical Care, and Perioperative Medicine
Clinical research spans acute coronary syndrome, cardiogenic shock, cardiac arrest, ECMO, heart disease, valvular heart disease, coronary heart disease, and aortic disorders. Perioperative studies also address postoperative delirium, major noncardiac surgery, and hemodynamic management in cardiac anesthesia.
- Acute coronary syndromes
- Extracorporeal membrane oxygenation
- Hemodynamic support
- Perioperative outcomes
Investigations include circulatory support, rhythm and flow optimization, and postoperative cognitive complications in high-risk patients.
Respiratory, Allergic, and Upper Airway Disease
The sponsor funds studies in severe asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, non-steroidal anti-inflammatory drug-exacerbated respiratory disease, respiratory insufficiency, respiratory failure, acute respiratory distress syndrome, and cystic fibrosis. Research also includes respiratory syncytial virus and airway barrier function.
- Severe asthma
- Chronic rhinosinusitis
- Airway epithelial barrier function
- Respiratory immunology
Therapeutic interest is centered on inflammatory airway disease, nasal polyposis, and biologic treatment responses in upper and lower airway disorders.
Oncology, Hematology, and Transplant-Related Malignancy
Research covers bladder cancer, urothelial carcinoma, prostate carcinoma, hepatocellular carcinoma, gastroesophageal cancer, triple negative breast cancer, advanced non small lung cancer, ROS1-positive non-small cell lung cancer, mantle cell lymphoma, and pediatric brain tumors including medulloblastoma, ependymoma, and atypical teratoid rhabdoid tumor.
- Solid tumors
- Hematologic malignancies
- CNS tumors
- Transplant-associated malignancy
Additional studies involve anti-angiogenic treatment approaches, CNS-directed therapy, and disease control in advanced or metastatic cancer.
Autoimmune, Inflammatory, Metabolic, and Neuropsychiatric Disorders
The trial portfolio includes rheumatoid arthritis, polymyalgia rheumatica, dermatomyositis, polymyositis, overlap myositis, cutaneous lupus erythematosus, acute graft-versus-host disease of the skin, major depressive disorder, obsessive compulsive disorder, anorexia nervosa, acromegaly, type 2 diabetes, prediabetes, obesity, hyperlipidemia, and hypogonadism.
- Autoimmune myopathy
- Inflammatory rheumatic disease
- Mood and anxiety disorders
- Metabolic disease
Interest also extends to autonomous cortisol secretion, vitamin D insufficiency, and bone and soft tissue healing, reflecting a broad focus on endocrine, metabolic, and inflammatory conditions.
