Oncology and tumour imaging
Clinical research spans solid tumours and haematological malignancies, with a strong emphasis on breast cancer, colorectal cancer, gastric cancer, pancreatic cancer, rectal cancer, melanoma, ovarian carcinoma, endometrial cancer, and lymphoma. Imaging-guided surgery and tumour delineation are central themes, including fluorescence-based approaches in the operating room and whole-body staging.
- Fluorescence-guided surgery
- Intraoperative tumour detection
- Colorectal and pancreatic malignancies
- Melanoma and brain metastases
Research also includes biomarkers and imaging tools for surgical planning, residual disease assessment, and improved localisation of metastatic or recurrent lesions.
Immunology, autoimmune disease, and transplantation
Investigations focus on systemic lupus erythematosus, rheumatoid arthritis, ANCA vasculitis, systemic sclerosis, and antibody-mediated rejection in kidney transplantation. The portfolio includes B-cell biology, germinal centre responses, HLA sensitisation, and immune modulation in both autoimmune and transplant settings.
- B-cell immune profiling
- HLA-specific memory responses
- Kidney graft rejection
- Autoantibody-driven disease
Additional work addresses vaccination responses in immunologically vulnerable groups, including patients without a spleen and individuals living with HIV infection.
Infectious diseases and vaccinology
Trial activity includes prevention and immune-response studies in malaria, influenza, rabies, mpox, shigellosis, yellow fever, and viral infections. The sponsor also studies host protection after vaccination across different populations, including healthy volunteers, children, older adults, and people with chronic disease.
- Vaccine immunogenicity
- Mucosal and systemic immunity
- Travel and tropical infections
- Antiviral and prophylactic strategies
Research extends to immune memory after primary vaccination and comparative responses to different vaccine platforms and routes of administration.
Pain medicine, anaesthesia, and respiratory physiology
Clinical studies address chemotherapy-induced neuropathic pain, chronic postoperative pain, cluster headache, migraine, renal colic, and pain associated with sternocostoclavicular hyperostosis and fibrous dysplasia. The programme also examines analgesic and anaesthetic interventions alongside their effects on breathing and ventilatory control.
- Neuropathic pain
- Post-surgical pain prevention
- Opioid-related respiratory depression
- Headache and facial pain disorders
Work in this area includes emergency pain management, regional techniques, and respiratory response studies linked to opioid and non-opioid agents.
Neurology, metabolic disease, and perioperative medicine
Research covers cerebral amyloid angiopathy, NF2-related schwannomatosis, Menière’s disease, bipolar disorder, type 1 diabetes, secondary hyperparathyroidism, urolithiasis, and venous thromboembolism. Trials also include perioperative infection prevention, thrombosis prophylaxis, and metabolic complications after bariatric or surgical care.
- Neurovascular and vestibular disorders
- Metabolic and endocrine complications
- Thrombosis prevention
- Postoperative infectious outcomes
Additional studies explore treatment options for opioid use disorder, traumatic brain injury, and inflammatory musculoskeletal conditions.
