Oncology and Haematologic Malignancies
Karolinska University Hospital supports clinical research across a broad range of cancer types, with particular activity in breast cancer, lung cancer, melanoma, gastrointestinal cancers, and gynaecological malignancies. Its portfolio also includes leukaemia, lymphoma, myelodysplastic syndrome, and neuroblastoma.
- HER2-positive and HER2-low breast cancer
- Acute myeloid leukaemia and acute lymphoblastic leukaemia
- Follicular lymphoma and other non-Hodgkin lymphoma subtypes
- Esophageal, gastric, pancreatic, and colorectal cancer
- Advanced solid tumours and metastatic melanoma
Research activity also extends to molecular imaging and biomarker-driven assessment in oncology, including work focused on tumour expression profiling and treatment selection.
Cardiovascular and Renal Medicine
The hospital funds studies in cardiovascular disease and kidney disease, with emphasis on rhythm disorders, thromboembolic prevention, and high-risk clinical settings. Areas of interest include atrial fibrillation, cardiac arrest, and treatment-resistant hypertension.
- Atrial fibrillation and post-procedural rhythm control
- Cardiac arrest and resuscitation care
- Chronic kidney disease stage 5
- Stroke prevention in patients with atrial fibrillation
- Resistant hypertension
Its research also covers cardiovascular risk in complex comorbidity settings, including patients with advanced renal impairment and those undergoing invasive cardiac treatment.
Autoimmune, Inflammatory, and Transplant-Related Disorders
Clinical studies at the hospital address rheumatoid arthritis, immune-related arthritis, primary sclerosing cholangitis, and hepatitis D, alongside immune-mediated complications in oncology and transplantation. The portfolio includes work in liver transplantation and strategies related to immune tolerance.
- Rheumatoid arthritis and disease control
- Immune checkpoint inhibitor-associated arthritis
- Primary sclerosing cholangitis
- Chronic hepatitis D
- Liver transplantation and immune modulation
Research also includes allergen immunotherapy and other immune-directed interventions in chronic inflammatory and hypersensitivity conditions.
Neurology, Endocrinology, and Metabolic Disease
The sponsor funds trials in Parkinson’s disease, brain tumour-related survivorship, type 1 diabetes, type 2 diabetes, and thyroid disease. Additional interest is seen in endocrine and metabolic disorders affecting reproductive and systemic health.
- Parkinson’s disease
- Diabetes mellitus and metabolic dysfunction
- Hyperthyroidism and toxic nodular goiter
- Brain tumour survivorship and cognitive effects
- Ovarian insufficiency and reproductive endocrinology
Its clinical research also includes attention to endocrine consequences of cancer treatment and hormone-related conditions, including climacteric symptoms and fertility-related outcomes.
Surgical Recovery, Reproductive Health, and Rare Conditions
Karolinska University Hospital also supports studies in post-operative recovery, female reproductive health, and selected rare or specialised conditions. These include recovery after major gastrointestinal and orthopaedic surgery, as well as disorders affecting sexual development and gender identity.
- Post-operative recovery after hip fracture surgery
- Recovery after gastrectomy or esophagectomy
- Autoimmune premature ovarian insufficiency
- Gender dysphoria and transsexual health
- Rare dermatologic and genetic disorders
Research in this area also includes fertility preservation, ovarian reserve, and symptom management in complex chronic disease settings.
