Oncology
Clinical research in solid tumours spans multiple advanced and metastatic cancer settings, with interest in disease control, tumour response, and treatment options after prior systemic therapy.
- Renal cell carcinoma
- Colorectal cancer
- Pancreatic adenocarcinoma
- Head and neck squamous cell carcinoma
- Melanoma
Research activity also includes locally advanced and metastatic solid tumour populations, with attention to immunotherapy-exposed disease and treatment-resistant cancer.
Hepatology and Cholestatic Liver Disease
Studies cover cholestatic liver disorders and related paediatric and adult conditions, with focus on symptom relief, liver function, and long-term disease management.
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Alagille syndrome
- Biliary atresia
Therapeutic interest extends to persistent pruritus and preservation of native liver survival in rare hepatobiliary disease.
Neurology and Movement Disorders
Clinical work in neurology includes treatment of upper limb spasticity across different causes, including post-stroke presentations, with emphasis on motor function and symptom reduction.
- Upper limb spasticity
- Post-stroke spasticity
- Spasticity of any aetiology
Research in this area reflects interest in managing functional impairment associated with neuromuscular tone abnormalities.
Targeted and Immuno-Oncology Therapeutics
Development programmes include investigational agents for advanced solid tumours, with attention to anti-tumour activity, pharmacodynamics, and treatment tolerability in adults with refractory disease.
- Immune checkpoint inhibitor-exposed tumours
- Pharmacokinetics and immunogenicity
- Antitumour activity
- Dose optimisation in selected tumours
These programmes include novel oncology compounds evaluated across several tumour types and treatment contexts.
Rare Disease and Gastrointestinal Supportive Care
Additional research interests include rare paediatric and hepatobiliary conditions, alongside disease-related symptom management and long-term safety in chronic disorders.
- Rare cholestatic disorders
- Paediatric liver disease
- Chronic pruritus
- Long-term safety in rare disease
Clinical activity also touches on advanced pancreatic cancer and other gastrointestinal malignancies, linking oncology with supportive disease management.
