Paediatric Bone Tumours
Clinical research at Instytut Matki I Dziecka includes treatment-focused studies in refractory primary bone tumors, with attention to Ewing’s sarcoma, high-grade osteosarcoma, and relapsed/refractory osteosarcoma. The work is centred on improving disease control in children and adolescents with difficult-to-treat skeletal malignancies.
- Refractory primary bone tumors
- Ewing’s sarcoma
- Osteosarcoma
Research interests also extend to event-free survival and the relationship between clinical outcomes and molecular characteristics of the tumour.
Histiocytic Disorders
The sponsor funds studies in histiocytic cell proliferation and histiocytosis in juvenile patients, including cases with BRAF-related disease. These trials address diagnostic and therapeutic needs in children with persistent or treatment-resistant histiocytic conditions.
- Histiocytic cell proliferation
- Histiocytosis
- BRAF-positive disease
Areas of interest include molecular profiling, mutation monitoring, and imaging assessment with 18F-FDG PET/CT.
Pediatric Oncology Therapeutics
Several trials focus on targeted therapy and oncology treatment strategies for paediatric and adolescent cancers, including agents studied in osteosarcoma, Ewing’s sarcoma, and histiocytic disorders. The therapeutic scope reflects active involvement in difficult malignancies requiring specialised oncological care.
- Targeted therapy
- Paediatric oncology
- Adolescent cancer care
Clinical interest includes treatment responses in refractory and conventional-therapy-resistant disease.
Maternal-Fetal Infectious Disease
Beyond oncology, the sponsor supports research in primary cytomegalovirus (CMV) infection during pregnancy, with emphasis on prevention of transmission and management of intrauterine infection. This extends its clinical research profile into maternal-fetal medicine and infectious disease.
- Primary cytomegalovirus (CMV) infection
- Pregnancy-related infection
- Intrauterine infection
The research addresses treatment options relevant to pregnant women with active viral infection.
