Neurodegenerative disease and brain imaging
Research activity includes Alzheimer’s disease, Lewy body dementia, Parkinson’s disease, prodromal Parkinson’s disease, semantic variant primary progressive aphasia, organic amnesia syndrome, and memory disorders across different clinical presentations. The funded studies use PET imaging, MRI, and functional neuroimaging to examine tau pathology, serotonergic dysfunction, microglial activation, and memory network integrity.
- Alzheimer’s pathology
- Parkinson’s disease biomarkers
- Neuroinflammation and tau imaging
- Memory network organisation
Additional work spans comatose traumatic brain injury and dopaminergic pathway abnormalities linked to recovery assessment.
Infectious diseases and viral prevention
The sponsor funds studies in HIV-1 infection, HIV prevention, HIV-HBV co-infection, COVID-19, and pneumonia. These trials focus on antiretroviral regimens, pre-exposure prophylaxis, viral control, and mucosal immunity, alongside immune responses in healthy volunteers and immunocompromised patients.
- HIV treatment and HIV prevention
- HBV control in co-infection
- COVID-19 vaccines and antivirals
- Respiratory infection management
Research also includes intranasal vaccination, long-acting PrEP, and antiviral strategies in people at increased risk of persistent infection.
Rare disease and gene therapy
Clinical research extends to recessive dystrophic epidermolysis bullosa, with interest in autologous skin grafting, COL7A1 gene correction, and ex vivo gene-modified tissue engineering. This area reflects a focus on inherited skin fragility disorders and regenerative approaches for severe genodermatoses.
- RDEB
- Autologous skin equivalents
- Gene-corrected grafts
- Inherited connective tissue repair
The portfolio also includes molecularly guided work in unresectable locally advanced and/or metastatic soft-tissue sarcoma.
Oncology and molecular profiling
Research in soft-tissue sarcoma emphasizes molecular tumour profiling, next-generation sequencing, and clinical recommendation pathways based on genomic findings. The sponsor’s oncology interests are concentrated on advanced disease characterization and biomarker-informed assessment.
- Advanced soft-tissue sarcoma
- Exome sequencing
- Molecular tumour board
- Genomic analysis
These studies align with broader efforts in precision oncology for difficult-to-treat malignancies.
Neurological pain, sleep, and neuropsychiatric conditions
Additional trials address central neuropathic pain after stroke, narcolepsy, and schizophrenia, with investigation of neural substrates, complement-related mechanisms, and sensory pathway modulation. This area links clinical symptoms with biological markers and brain circuit function.
- Post-stroke central pain
- Narcolepsy
- Schizophrenia
- Complement C4 and brain inflammation
Related work also includes studies in healthy volunteers to support comparison across neurological and psychiatric conditions.
