Oncology and rare cancers
Clinical research covers advanced and metastatic solid tumours, with particular attention to mesothelioma, gastric adenocarcinoma, ovarian cancer, neuroendocrine carcinoma, thymic malignancies, anaplastic thyroid carcinoma, and gestational trophoblastic neoplasia. The portfolio also includes studies in metastatic prostate cancer and other treatment-resistant cancers.
- Malignant pleural and peritoneal mesothelioma
- Advanced gastric cancer
- Rare thoracic and endocrine tumours
- Gastro-enteropancreatic neuroendocrine neoplasms
Research interest extends to immunotherapy, targeted cancer treatment, and surgical or locoregional management in advanced disease.
Neurology, neuroimaging, and movement disorders
Trials address Parkinson disease, Tourette disorder, epilepsy, cluster headache, stroke, intracerebral haemorrhage, transient ischemic attack, and broader nervous system diseases. Several studies focus on brain receptor pathways, functional connectivity, and inflammatory imaging markers.
- Parkinson disease
- Epilepsy and seizure disorders
- Tourette disorder
- Stroke and cerebrovascular disease
There is also interest in PET-MRI, serotonergic pathways, and adrenergic receptor biology.
Pulmonary, critical care, and infectious disease
The sponsor funds studies in asthma, idiopathic pulmonary fibrosis, ventilator-acquired pneumonia, and septic shock. Research also includes inflammatory and immune-related respiratory conditions such as extra-pulmonary sarcoidosis.
- Asthma
- Idiopathic pulmonary fibrosis
- Ventilator-acquired pneumonia
- Septic shock
Additional work explores immune modulation in acute infection and respiratory failure.
Autoimmune, transplant, and haematology
Clinical activity includes systemic lupus erythematosus, ANCA-associated vasculitis, granulomatosis with polyangiitis, microscopic polyangiitis, renal transplantation, and allogeneic haematopoietic stem cell transplantation. These studies reflect interest in immune-mediated disease, graft outcomes, and transplant-related immunosuppression.
- Systemic lupus erythematosus
- ANCA-associated vasculitis
- Kidney transplantation
- Haematopoietic stem cell transplantation
Research also touches on graft rejection and immune recovery after transplantation.
Dermatology, ophthalmology, and paediatric care
Further trials involve Stevens-Johnson syndrome, toxic epidermal necrolysis, bilateral limbal stem cell deficiency, diabetic macular oedema, and cerebral palsy with pathological drooling. The portfolio also includes obesity in children and adolescents, postoperative pain, and drug dependence.
- Severe bullous skin reactions
- Limbal stem cell deficiency
- Diabetic macular oedema
- Paediatric neurological and functional disorders
These studies span skin regeneration, vision-threatening disease, and supportive care in paediatrics.
