Groupe Hospitalier Universitaire Paris Psychiatrie Et Neuroscience

Neurodegenerative disease

Clinical research in Alzheimer disease focuses on disease progression, cognitive decline, and the relationship between microglial activation, tau pathology, and synaptic density using positron emission tomography imaging.

  • Alzheimer disease
  • Cognitive impairment
  • Neuroinflammation
  • Synaptic loss

Research activity also includes biomarker-oriented work in early Alzheimer disease and longitudinal assessment of neurological deterioration.

Psychiatry and psychosis

Trials in early psychosis, ultra high risk of psychosis, and first episode psychosis examine personalised care, functional recovery, and digital cognitive support, with additional interest in treatment-resistant depression.

  • Early psychosis
  • Ultra high risk of psychosis
  • First episode psychosis
  • Treatment-resistant depression

The sponsor also studies global functioning, neuropsychiatric symptoms, and psychotherapeutic support in mood and psychotic disorders.

Neurovascular injury

Research in aneurysmal subarachnoid hemorrhage addresses neurological recovery, functional outcome, and post-hemorrhagic disability in patients with acute cerebrovascular injury.

  • Aneurysmal subarachnoid hemorrhage
  • Neurological outcome
  • Functional recovery
  • Acute brain injury

These studies place emphasis on longer-term disability assessment and recovery after severe vascular events affecting the brain.

Eating and metabolic disorders

Clinical work in anorexia nervosa explores symptom improvement and neurobiological mechanisms relevant to severe restrictive eating disorders.

  • Anorexia nervosa
  • Eating disorder symptoms
  • Neurocognitive mechanisms

This area connects psychiatric care with investigations into behavioural and biological factors involved in disordered eating.

Experimental neuroscience in healthy volunteers

Studies in healthy subjects examine learning dynamics, noradrenergic system function, pupil diameter, and electroencephalographic responses to better understand normal cognitive processing.

  • Healthy subjects
  • Learning dynamics
  • Noradrenergic system
  • EEG responses

These investigations support translational neuroscience across cognitive and psychiatric domains.

Want to learn more about this study or check if you can participate? Contact us.

Matched clinical trials

  • Effect of atomoxetine on learning dynamics in healthy adults: a study comparing single dose atomoxetine 40 mg with placebo

    Recruiting

    1 1
    Investigated drugs:
    France
  • Study of cilostazol and nimodipine combination to improve outcomes in patients with aneurysmal subarachnoid hemorrhage

    Recruiting

    1 1 1
    Investigated diseases:
    France
  • Study on the Effects of Donepezil in Patients with Anorexia Nervosa

    Recruiting

    1 1
    Investigated diseases:
    Investigated drugs:
    France
  • Study on Psilocybin and Trazodone for Adults with Treatment-Resistant Depression

    Not yet recruiting

    1 1
    France
  • Study on the Effectiveness of Calcium Folinate, Omega-3-Acid Ethyl Esters, and Cyanocobalamin for Patients at High Risk of Psychosis or Experiencing First Episode Psychosis

    Not yet recruiting

    1 1 1 1
    Investigated diseases:
    France
  • Study of microglial activation and synaptic density using [18F]-DPA-714, [18F]-Ro948, [11C]-UCB-J, and [11C]PiB PET imaging in patients with Alzheimer’s disease

    Not recruiting

    1 1
    Investigated diseases:
    France