Paediatric haematology and leukaemia
Research activity includes acute myeloid leukaemia, myeloid leukaemia in children with Down syndrome, and relapsed or refractory AML, with attention to treatment options for newly diagnosed and high-risk disease.
- Acute Myeloid Leukemia
- Myeloid Leukemia in Children with Down Syndrome
- Relapsed or refractory AML
Additional interest extends to event-free survival, overall survival, and conditioning regimens in childhood leukaemia care.
Paediatric solid tumours and sarcoma
The sponsor supports studies in Ewing sarcoma, including high-risk and standard-risk disease, as well as stage IV childhood renal tumour with metastatic spread.
- Ewing Sarcoma
- Stage IV childhood renal tumour
- Metastatic disease
Clinical interest also covers systemic therapy, metastatic response, and maintenance treatment in aggressive paediatric tumours.
Paediatric brain tumours
Research spans atypical teratoid/rhabdoid tumours (ATRT) and medulloblastoma, including SHH-activated, TP53-wild-type, and non-MYC amplified subtypes.
- Atypical teratoid/rhabdoid tumours (ATRT)
- Medulloblastoma
- Neurocognitive outcomes
Key areas include survival outcomes, radiotherapy, and long-term neurocognitive function in children and adolescents.
Lymphoma and head and neck cancer
The clinical portfolio includes standard-risk ALK-positive anaplastic large cell lymphoma (ALCL) and EBV-positive nasopharyngeal carcinoma in children, adolescents, and young adults.
- ALK-positive anaplastic large cell lymphoma (ALCL)
- EBV-positive nasopharyngeal carcinoma
- Induction chemotherapy
These studies address treatment response, radiotherapy adaptation, and disease control across locoregional and systemic settings.
