Cardiovascular and Renal Disease
Research activity includes heart failure with preserved ejection fraction, moderate chronic renal disease, and secondary prevention of vascular events in patients with impaired kidney function. The portfolio also covers the interaction between cardiovascular risk and renal progression.
- Heart failure with preserved ejection fraction
- Chronic renal disease
- Cardiovascular event prevention
- Renal progression
These studies reflect a strong interest in mechanisms linking cardiac function and kidney disease, with attention to long-term clinical outcomes.
Transplantation and Immune Tolerance
The sponsor funds work in paediatric heart transplantation and acute rejection prevention, including the use of regulatory T cells and autologous thyTreg cells. This area is closely tied to immune modulation in transplant care.
- Paediatric heart transplantation
- Acute rejection
- Regulatory T cells
- Immune tolerance
Clinical interest extends to cell-based therapies aimed at supporting graft acceptance in vulnerable transplant recipients.
Infectious Complications and Critical Care
Trials address cytomegalovirus management in high-risk surgical patients and immune hyperactivation in COVID-19 and acute respiratory distress syndrome. The research focus includes infection-related complications in cardiac surgery and critical illness.
- Cytomegalovirus
- Major heart surgery
- COVID-19
- Acute respiratory distress syndrome
These studies examine infectious and inflammatory risks in hospitalised and intensive care settings.
Renal Protection in Complex Surgery
Research includes acute kidney injury associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy using cisplatin. The sponsor also studies strategies for renal protection in the postoperative period.
- Acute kidney injury
- Cisplatin-related nephrotoxicity
- Postoperative renal injury
- Oncologic surgery
This area links surgical oncology with preservation of kidney function during intensive treatment.
Neurodevelopmental Disorders
The sponsor also supports research in autism spectrum disorder, with interest in social function and related neurobiological features. This adds a distinct paediatric neuropsychiatric dimension to the portfolio.
- Autism spectrum disorder
- Social function
- Paediatric neuropsychiatry
The research activity in this area focuses on clinical questions relevant to children and adolescents with developmental and behavioural needs.
