Paediatric Oncology and Cellular Immunotherapy
Fundacio Sant Joan De Deu supports clinical research in aggressive childhood cancers, with particular interest in acute lymphoblastic leukemia, neuroblastoma, and diffuse intrinsic pontine glioma. The funded studies include advanced CAR-T cell approaches, immunotherapy, and treatment strategies for difficult-to-treat paediatric malignancies.
- CD19+ acute lymphoblastic leukemia
- High-risk neuroblastoma
- Diffuse intrinsic pontine glioma
- Anti-IL13Ra2 CAR-T cells
- Dendritic cell immunisation
Its oncology portfolio also includes research on refractory paediatric leukaemia and tumour-directed immunotherapies for newly diagnosed and treatment-resistant disease.
Inherited Metabolic and Neurological Disorders
The sponsor funds studies in mitochondrial disorders and cerebellar ataxias, reflecting a strong therapeutic interest in rare neurometabolic diseases and disorders affecting coordination and neurological function.
- Mitochondrial disease
- Cerebellar ataxia
- Ubiquinol
- Genetic diagnosis
Research in this area focuses on children and adults with confirmed or suspected rare neurological conditions.
Congenital Heart Disease and Cardiac Imaging
Fundacio Sant Joan De Deu is involved in paediatric cardiac research spanning cardiomyopathy, tetralogy of Fallot, and complex congenital heart disease, alongside work on improved cardiac MRI assessment in children.
- Cardiomyopathy
- Tetralogy of Fallot
- Complex congenital heart disease
- Paediatric cardiac MRI
- Contrast-enhanced imaging
The sponsor’s interest includes diagnostic imaging tools used to characterise structural and functional heart disease in paediatric patients.
Paediatric Vascular and Interventional Disorders
The clinical trial portfolio includes research on venous malformation and low-flow venous/lymphatic malformation, with attention to complications linked to interventional procedures and vascular coagulopathy in children.
- Venous malformation
- Low-flow vascular malformation
- Localized intravascular coagulopathy
- Paediatric interventional procedures
This area reflects a focus on vascular anomalies requiring specialist procedural care and complication prevention.
Endocrine and Reproductive Health in Adolescents and Young Adults
The sponsor also funds research in polycystic ovary syndrome (PCOS), with interest in restoring ovulatory function in adolescents and young adult women.
- Polycystic ovary syndrome (PCOS)
- Ovulation normalisation
- Adolescent and young adult women
Its research activity in this domain addresses endocrine and reproductive health concerns in a younger female population.
