Ophthalmology and Ocular Surface Disease
Research activity is concentrated in dry eye disease, atopic keratoconjunctivitis, ocular inflammatory conditions, and persistent corneal epithelial defect, with additional work in dry eye symptom control and ocular itching.
- Recombinant human nerve growth factor ophthalmic treatment
- Isocyclosporin A eye drop therapy
- Cenegermin for corneal healing
- Vehicle-controlled ocular symptom studies
The portfolio also includes investigations in corneal epithelial repair and inflammatory eye disease, reflecting a strong focus on surface ocular disorders.
Respiratory and Critical Care
Clinical research includes acute respiratory distress syndrome, with attention to lung injury, systemic inflammation, and recovery in patients requiring mechanical ventilation.
- Hyper-inflammatory ARDS
- Respiratory failure support
- Inflammation-linked biomarkers
- Clinical recovery in intensive care settings
This area is centered on severe pulmonary disease and the inflammatory pathways associated with critical illness.
Neurology and Neurodevelopmental Disorders
Research spans spastic cerebral palsy and subacute moderate to severe traumatic brain injury, with interest in neurological function, tolerance, and recovery in pediatric and adult populations.
- Intranasal cenegermin
- Traumatic brain injury care
- Cerebral palsy in pediatric participants
- Neurological safety and tolerability
The portfolio includes both developmental and acquired neurological conditions, covering motor impairment and brain injury.
Endocrinology and Metabolic Disease
Clinical studies address recent onset type 1 diabetes, with emphasis on preserving beta-cell function and limiting progression of autoimmune metabolic disease in adolescents and adults.
- Type 1 diabetes intervention research
- Beta-cell preservation
- Adolescent and adult diabetes
- Autoimmune disease progression
This area reflects a focus on early disease management in immune-mediated diabetes.
Pain and Urogenital Disorders
Additional research includes chronic low back pain and interstitial cystitis/bladder pain syndrome, covering persistent pain conditions and urinary tract discomfort.
- Chronic pain management
- Bladder pain syndrome
- Musculoskeletal pain
- Quality-of-life symptom burden
These studies extend the sponsor’s interest into long-term pain syndromes and urological symptom relief.
