Neurodegenerative disease and brain imaging
Clinical research includes Alzheimer’s disease and related cognitive disorders, with a focus on PET/CT imaging of tau and amyloid pathology in the brain.
- Alzheimer’s disease
- mild cognitive impairment
- neuroimaging biomarkers
Work in this area also covers comparison with control populations to characterise regional protein deposition patterns across neurodegenerative conditions.
Autoimmune and inflammatory disease
Trials address rheumatoid arthritis and severe allergic and eosinophilic asthma, with interest in immune-cell activity, synovial tissue biology, and inflammatory control.
- rheumatoid arthritis
- severe allergic and eosinophilic asthma
- synovial biopsies
Research also examines blood-based T-cell peptide responses and immunohistochemical features linked to immune-mediated disease.
Cardiac and vascular disorders
Investigation extends to cardiac sarcoidosis and arterio-venous malformations, with emphasis on inflammatory cardiac lesions and complex vascular anomalies.
- cardiac sarcoidosis
- arterio-venous malformations
- cardiac inflammation
Imaging-based assessment is used to explore lesion detection in the heart and symptom burden in refractory vascular disease.
Head and neck cancer
Oncology activity includes locally advanced head and neck squamous cell carcinoma and squamous cell carcinoma of the head and neck, with attention to immune markers and residual disease assessment.
- locally advanced head and neck squamous cell carcinoma
- HPV-negative head and neck cancer
- ctDNA-positive disease
Research also involves peptide-based immunotherapy and PD-L1-associated treatment selection in this tumour group.
Renal cancer
Studies in metastatic clear cell renal carcinoma focus on PSMA imaging and treatment response assessment in advanced kidney cancer.
- metastatic clear cell renal carcinoma
- PSMA PET/CT
- treatment response biomarkers
This area reflects interest in using molecular imaging to characterise disease activity and support evaluation of anticancer therapy.
