Gastrointestinal oncology
Clinical research includes colorectal cancer, rectal cancer, small bowel adenocarcinoma, and ampullary adenocarcinoma, with interest in neoadjuvant and adjuvant chemotherapy, ctDNA-guided treatment, and surgery-related cancer care. Studies also extend to advanced gastroenteropancreatic neuroendocrine carcinoma.
- Colorectal cancer
- Rectal cancer
- Small bowel adenocarcinoma
- Ampullary adenocarcinoma
The sponsor is active in perioperative and post-surgical oncology, including strategies linked to microsatellite instability and mismatch repair deficiency.
Endocrinology and metabolic disease
Research activity covers type 1 diabetes with double diabetes features, focusing on glycaemic control and metabolic management. The portfolio also includes rare familial polycythemia associated with an EPO gene mutation.
- Type 1 diabetes
- Double diabetes
- Familial polycythemia
- EPO gene mutation
These studies reflect interest in complex metabolic phenotypes and inherited haematologic conditions.
Ophthalmology
The sponsor funds trials in diabetic macular oedema and macular telangiectasia type 1, with attention to retinal thickness, visual outcomes, and intravitreal treatment options. Research also addresses resistant retinal disease in people with diabetes.
- Diabetic macular oedema
- Macular telangiectasia type 1
- Retinal disease
- Intravitreal therapy
Its ophthalmic work spans both diabetic and non-diabetic retinal disorders.
Rheumatology and inflammatory disease
Clinical studies include giant cell arteritis and treatment strategies involving tocilizumab and methotrexate. The portfolio also includes autoimmune hemolytic anemia and aspirin use in acute pneumonia.
- Giant cell arteritis
- Autoimmune hemolytic anemia
- Inflammatory disease
- Acute pneumonia
These trials show interest in immune-mediated disease control and complications of systemic inflammation.
Critical care, urology, and neurological disorders
Research extends to vasoplegic syndrome, norepinephrine-refractory vasoplegic shock, and perioperative haemodynamic management in cardiac surgery. Additional studies address recurrent urinary tract infections, neurogenic bladder, and rare neurological conditions including TBR1-related neurocognitive disorder and Megalencephaly-CApillary malformation Polymicrogyria syndrome.
- Vasoplegic syndrome
- Refractory vasoplegic shock
- Neurogenic bladder
- TBR1-related neurocognitive disorder
The sponsor also studies idiopathic pulmonary fibrosis, broadening its interest in severe respiratory disease.
