Cardiovascular and Antithrombotic Care
Clinical research at Centre Hospitalier Universitaire De Caen Normandie includes atrial fibrillation, anticoagulation, and antiplatelet therapy in adults with complex cardiovascular profiles. The sponsor also studies treatment strategies after percutaneous coronary intervention and transcatheter aortic valve implantation, with attention to bleeding risk and long-term vascular protection.
- Non-valvular atrial fibrillation
- Peritoneal dialysis and stroke prevention
- Drug-eluting stents and post-PCI antiplatelet care
- TAVI and antithrombotic management
The cardiovascular portfolio also extends to elderly patients and those with preserved left ventricular function, reflecting interest in balancing efficacy and safety in chronic thromboembolic and bleeding-sensitive settings.
Infectious Diseases and HIV
The sponsor supports trials in HIV-1 care for virologically controlled patients with prior M184V/I mutation, focusing on maintenance of viral suppression and treatment options for resistant infection histories. This area reflects a sustained interest in long-term management of chronic viral disease.
- HIV-1 virological control
- Antiretroviral therapy selection
- Drug-resistance mutation history
Research in this domain is centered on maintaining stable control in adults living with HIV while addressing prior resistance patterns that may influence therapeutic choices.
Rheumatology and Inflammatory Vascular Disease
Another key area is giant cell arteritis, with studies examining corticosteroid therapy approaches and remission outcomes. The sponsor’s work in this field is tied to inflammatory vascular disease and the management of relapse risk in older adults.
- Giant cell arteritis
- Corticosteroid treatment
- Relapse prevention
This research domain addresses disease control in vasculitis and the clinical course of patients requiring prolonged anti-inflammatory treatment.
Perioperative Medicine and Anesthesiology
The sponsor also investigates neuromuscular blockade reversal and perioperative drug use, including rocuronium and sugammadex in young children undergoing surgery. This area covers anesthetic management across adult and pediatric populations.
- Rocuronium reversal
- Sugammadex use
- Pediatric anesthesia
- Perioperative neuromuscular management
Research in this field includes surgical patients requiring controlled muscle relaxation and safe recovery of neuromuscular function.
Palliative and Symptom-Relief Care
Clinical activity also covers palliative care, with interest in pain management and the use of paracetamol in patients with advanced illness and central venous access. This area focuses on symptom control in adults receiving comprehensive end-of-life care.
- Palliative pain management
- Paracetamol administration routes
- Advanced illness care
The sponsor’s work in this domain is linked to practical management of discomfort in patients with limited curative options.
