Oncology
The sponsor’s oncology portfolio spans non-small cell lung cancer, melanoma, urothelial cancer, breast cancer, colorectal cancer, pancreatic ductal adenocarcinoma, gastric and gastroesophageal cancers, hepatocellular carcinoma, renal cell carcinoma, ovarian cancer, bladder cancer, and myelofibrosis. It also includes studies in acute myeloid leukemia, myelodysplastic syndrome, primary central nervous system lymphoma, and other advanced solid tumors.
- Immuno-oncology
- Targeted therapy
- Metastatic cancer
- Hematologic malignancies
- Perioperative and first-line cancer treatment
Research activity includes treatment of EGFR-mutated and KRAS G12C-mutant disease, as well as platinum-resistant and unresectable cancer settings.
Autoimmune and inflammatory disease
Clinical research in immune-mediated disease centers on systemic lupus erythematosus, cutaneous lupus erythematosus, psoriatic arthritis, plaque psoriasis, rheumatoid arthritis, Sjögren’s syndrome, systemic sclerosis, idiopathic inflammatory myopathy, ulcerative colitis, and atopic dermatitis.
- Systemic lupus erythematosus
- Psoriatic arthritis
- Psoriasis
- Inflammatory bowel disease
- Connective tissue disease
Additional work extends to juvenile psoriatic arthritis and pediatric immune-mediated conditions.
Neurology and psychiatry
The sponsor funds trials in Alzheimer’s disease, including early and mild to moderate stages, with associated agitation and psychosis. Its neuroscience portfolio also includes bipolar I disorder, mania, schizophrenia, and relapsing remitting multiple sclerosis.
- Alzheimer’s disease
- Bipolar I disorder
- Schizophrenia
- Multiple sclerosis
- Neuropsychiatric symptoms
Research also addresses primary central nervous system lymphoma within the broader neuro-oncology landscape.
Pulmonary and cardiovascular disease
Respiratory and cardiometabolic studies include idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, and heart failure with preserved ejection fraction. Cardiovascular research also covers symptomatic obstructive hypertrophic cardiomyopathy.
- Interstitial lung disease
- Pulmonary fibrosis
- Heart failure
- Hypertrophic cardiomyopathy
These programs reflect interest in chronic cardiopulmonary disorders with significant unmet treatment need.
Hematology, transplantation, and rare disease
Additional clinical work includes sickle cell disease, renal transplantation, and adolescent renal allograft care, alongside studies in myelofibrosis and other hematologic disorders. The portfolio also extends to urothelial carcinoma and solid malignancies with high-risk or refractory features.
- Sickle cell disease
- Renal transplantation
- Myelofibrosis
- Urothelial carcinoma
Research activity in these areas spans both chronic disease management and oncology-linked rare conditions.
