Oncology and Targeted Cancer Therapy
Clinical research spans non-small cell lung cancer, small cell lung cancer, neuroendocrine neoplasms, HER2-mutated solid tumours, pancreatic ductal adenocarcinoma, biliary tract cancer, urothelial bladder cancer, gastric and gastroesophageal junction adenocarcinoma, colorectal cancer, breast cancer, melanoma, and dedifferentiated liposarcoma.
- HER2-driven malignancies
- DLL3-expressing neuroendocrine cancers
- Advanced solid tumours
- Metastatic and unresectable cancer
Research also includes tumour-directed approaches across gastrointestinal, thoracic, and genitourinary oncology, with attention to objective response, progression-free survival, and disease control.
Pulmonary and Fibrotic Lung Disease
The sponsor funds studies in idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, progressive fibrosing interstitial lung diseases, systemic sclerosis-associated interstitial lung disease, childhood interstitial lung disease, bronchiectasis, cystic fibrosis bronchiectasis, and cystic fibrosis.
- Interstitial lung diseases
- Pulmonary fibrosis
- Chronic cough
- Airway inflammation and lung function
Additional work covers respiratory symptom burden and long-term management of fibrosing lung disorders, with outcomes tied to forced vital capacity and exacerbations.
Cardiometabolic, Renal, and Hepatic Disease
Research activity includes heart failure, acute myocardial infarction, cardiovascular disease, hypertension, type 2 diabetes, obesity, overweight, chronic kidney disease, proteinuric kidney disease, renal impairment, liver cirrhosis, portal hypertension, and metabolic dysfunction-associated steatohepatitis.
- Cardiorenal syndromes
- Congestive heart failure
- Advanced fibrosis and cirrhosis
- Metabolic liver disease
Trials also address haemodynamic liver complications, kidney function decline, and cardiometabolic risk in populations with overlapping diabetes and vascular disease.
Dermatology, Autoimmune Disease, and Rare Inflammatory Disorders
Clinical studies extend to hidradenitis suppurativa, generalized pustular psoriasis, plaque psoriasis, pyoderma gangrenosum, Netherton syndrome, systemic lupus erythematosus, systemic sclerosis, type 1 interferonopathies, and systemic autoimmune rheumatic diseases.
- Immune-mediated skin disease
- Autoinflammatory disorders
- Connective tissue disease
- Recurrent flare management
Work in this area includes chronic inflammatory dermatoses and rare immune conditions where symptom burden, flare control, and longer-term disease activity are central concerns.
Ophthalmology, Neurology, and Psychiatry
The portfolio also covers diabetic retinopathy, centre-involved diabetic macular edema, acute ischemic stroke, attention deficit hyperactivity disorder, schizophrenia, major depressive disorder, and borderline personality disorder.
- Retinal vascular disease
- Neuropsychiatric disorders
- Stroke and cerebrovascular disease
- Cognitive impairment in schizophrenia
These studies include vision-threatening diabetic eye disease and central nervous system disorders with emphasis on functional outcomes, symptom relief, and disease progression.
