Interstitial lung disease and fibrotic lung disorders
Research activity includes idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, progressive fibrosing interstitial lung diseases, and systemic sclerosis-associated interstitial lung disease, with additional interest in rheumatic disease-related lung fibrosis and lung function decline.
- Pulmonary fibrosis
- Interstitial lung disease
- Systemic sclerosis
- Respiratory symptom burden
Additional work extends to cough in fibrotic lung disease and related respiratory impairment.
Dermatology and immune-mediated skin disease
The sponsor funds studies in generalized pustular psoriasis, hidradenitis suppurativa, pyoderma gangrenosum, and Netherton syndrome, reflecting a strong focus on severe inflammatory and rare dermatologic conditions.
- Generalized pustular psoriasis
- Hidradenitis suppurativa
- Pyoderma gangrenosum
- Netherton syndrome
Interest also includes recurrent flares and longer-term management of chronic skin inflammation.
Oncology across solid tumours and hematology-related cancers
Clinical research spans non-small cell lung cancer, small cell lung carcinoma, HER2-driven solid tumours, pancreatic cancer, biliary tract cancer, urothelial bladder cancer, glioblastoma, glioma, and dedifferentiated liposarcoma.
- HER2-mutated cancers
- Advanced solid tumours
- Pancreatic and biliary cancers
- Neuro-oncology
Further activity covers extrapulmonary neuroendocrine carcinoma and other advanced malignancies.
Kidney disease, cardiometabolic disease, and heart failure
Research includes chronic kidney disease, proteinuric kidney disease, focal segmental glomerulosclerosis, and other glomerular disorders, alongside studies in type 2 diabetes, obesity, hypertension, and cardiovascular disease.
- Chronic kidney disease
- Glomerular disease
- Type 2 diabetes
- Cardiovascular risk
Additional interest extends to myocardial infarction, heart failure, and obesity-related metabolic disease.
Liver disease, cystic fibrosis, and rare inflammatory disorders
The portfolio also covers portal hypertension in cirrhosis, including clinically significant portal hypertension, as well as cystic fibrosis and cystic fibrosis-related bronchiectasis. Rare immune and inflammatory conditions such as systemic lupus erythematosus and type 1 interferonopathies are also represented.
- Portal hypertension
- Cirrhosis
- Cystic fibrosis
- Autoimmune disease
Work in bronchiectasis and related chronic airway disease further broadens the respiratory research focus.
