Onco-Hematology and Bone Marrow Malignancies
Clinical research includes acute leukemias, multiple myeloma, myelodysplastic syndrome, myelofibrosis, primary CNS lymphoma, and other hematologic malignancies, with strong activity in stem cell transplantation and transplant-related complications.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Multiple myeloma
- Allogeneic hematopoietic stem cell transplantation
- Graft-versus-host disease
Research also covers lymphoma, plasma cell leukemia, and post-transplant immune complications in adult and pediatric populations.
Critical Care, Sepsis, and Infectious Diseases
The sponsor is active in intensive care medicine and severe infection management, including septic shock, community-acquired pneumonia, ventilator-associated pneumonia, candidemia, cytomegalovirus infection, and multidrug-resistant bacterial infections.
- Sepsis
- Septic shock
- Ventilator-associated pneumonia
- Invasive mechanical ventilation
- Antimicrobial and antiviral treatment
Studies also address post-ICU complications, acute respiratory failure, and infection-related organ dysfunction in both adults and children.
Autoimmune, Inflammatory, and Rheumatologic Diseases
Research spans vasculitis, systemic sclerosis, sarcoidosis, myositis, lupus, rheumatoid-spectrum inflammatory disease, and autoinflammatory syndromes, with a marked focus on immune-mediated organ injury.
- ANCA-associated vasculitis
- Takayasu arteritis
- Systemic sclerosis
- Inflammatory bowel disease
- Familial Mediterranean fever
Additional work involves uveitis, cryoglobulinemic vasculitis, Behçet’s disease, and immune thrombocytopenia.
Cardiovascular, Cerebrovascular, and Cardiorenal Disorders
Clinical studies address acute myocardial infarction, heart failure, cardiogenic shock, valvular heart disease, stroke, pulmonary hypertension, and thromboembolic disease, alongside related renal and vascular complications.
- Myocardial infarction
- Ischemic stroke
- Heart failure
- Pulmonary arterial hypertension
- Kidney injury and transplant-related disease
Research also includes atrial arrhythmias, aortic and tricuspid valve disease, venous thromboembolism, and renal transplant rejection.
Neurology, Respiratory Medicine, and Perinatal Care
The portfolio includes amyotrophic lateral sclerosis, multiple sclerosis, brain tumors, neurodevelopmental disorders, depression, and pain management, together with asthma, chronic respiratory failure, and severe lung disease.
- Amyotrophic lateral sclerosis
- Multiple sclerosis
- Severe asthma and respiratory insufficiency
- Major depressive disorder
- Pregnancy and neonatal complications
Trials also cover infertility, preterm birth, neonatal intensive care, pediatric pain, and neurologic injury in critically ill patients.
