Oncology and Hematologic Malignancies
Amgen Inc. funds research across a broad oncology portfolio spanning non-small cell lung cancer, small cell lung cancer, metastatic castration-resistant prostate cancer, gastric and gastroesophageal junction cancer, colorectal cancer, melanoma, acute lymphoblastic leukemia, and solid tumors with molecular targets such as KRAS p.G12C and MTAP deletion.
- Advanced solid tumors
- KRAS-altered cancers
- Small cell lung cancer
- Prostate cancer
- Hematologic malignancies
Its cancer research also includes biomarker-defined disease groups such as FGFR2b-overexpressing tumors, MSI-H/dMMR solid tumors, and PD-L1-negative disease.
Inflammatory and Autoimmune Diseases
The sponsor supports studies in immune-mediated disorders including atopic dermatitis, asthma, ulcerative colitis, antineutrophil cytoplasmic antibody-associated vasculitis, Behçet’s disease, juvenile idiopathic arthritis, juvenile psoriatic arthritis, and Sjögren’s syndrome.
- Atopic dermatitis
- Asthma
- Ulcerative colitis
- Vasculitis
- Pediatric autoimmune disease
Additional interest extends to IgG4-related disease, generalized myasthenia gravis, and relapsing-remitting multiple sclerosis.
Cardiovascular and Metabolic Disorders
Amgen Inc. also funds research in cardiovascular disease, with studies in atherosclerotic cardiovascular disease, high cardiovascular risk, acute myocardial infarction, dyslipidemia, elevated lipoprotein(a), and heart failure with preserved or mildly reduced ejection fraction.
- Atherosclerotic cardiovascular disease
- Acute myocardial infarction
- Dyslipidemia
- Heart failure
- Obesity-related cardiovascular risk
Its metabolic research includes overweight and obesity, type 2 diabetes mellitus, chronic weight management, and obstructive sleep apnea associated with excess body weight.
Neurology and Pain Disorders
The portfolio includes neurologic and pain-related conditions such as chronic migraine, episodic migraine, and relapsing-remitting multiple sclerosis, along with pediatric and adult immune-neurologic conditions.
- Chronic migraine
- Episodic migraine
- Multiple sclerosis
- Generalized myasthenia gravis
Research in this area also touches on central nervous system autoimmune disease and neuromuscular weakness.
Bone, Kidney, and Rare Disease Areas
Amgen Inc. funds studies in osteogenesis imperfecta, secondary hyperparathyroidism in pediatric patients with chronic kidney disease on hemodialysis, and other rare or specialized disorders affecting skeletal and mineral metabolism.
- Osteogenesis imperfecta
- Chronic kidney disease
- Secondary hyperparathyroidism
- Thyroid eye disease
Its research also includes prurigo nodularis and moderate to severe plaque psoriasis, reflecting interest in chronic dermatologic and inflammatory conditions.
