Infectious Diseases and Viral Illness Research

At San Raffaele Scientific Institute in Milan, clinical trials in Infectious Diseases focus on virus diseases and related public health concerns, with studies centered on mpox virus disease and emerging infectious threats. The research aims to improve understanding of clinical outcomes and evaluate how antiviral treatment may support patient care.

  • Clinical outcomes in mpox virus disease with and without antiviral treatment
  • Assessment of treatment effectiveness in viral infections
  • Public health-oriented research on infectious disease management

This area reflects the site’s strong role in studying real-world responses to viral disease while supporting better care strategies for patients and clinicians.

Respiratory, Digestive, and Immune-Mediated Diseases

Research here also spans respiratory tract diseases, digestive system diseases, and immune system diseases, with trials addressing conditions such as pneumonia, eosinophilic esophagitis, and eosinophilic granulomatosis with polyangiitis. These studies are designed to test new therapies and improve disease control in patients with complex inflammatory and allergic disorders.

  • Therapy evaluation in eosinophilic esophagitis
  • Clinical research in eosinophilic granulomatosis with polyangiitis
  • Studies in pneumonia and other respiratory infections

The portfolio highlights ongoing efforts to refine treatment options for chronic inflammatory disease and acute infection alike.

Hematology and Blood Cancer Studies

A major focus is hemic and lymphatic diseases, especially chronic lymphocytic leukemia, small lymphocytic lymphoma, and acute myeloid leukemia. These trials are evaluating new treatment approaches and strategies to improve disease control, long-term outcomes, and safety in blood cancers.

  • Treatment research in chronic lymphocytic leukemia and small lymphocytic lymphoma
  • Studies in acute myeloid leukemia focused on improving transplant-related care
  • Evaluation of new oncology approaches for hematologic malignancies

This work supports advances in personalized hematology care through trials that compare treatment approaches and examine patient benefit over time.

Oncology and Solid Tumor Research

The site conducts broad neoplasms research across breast cancer, non-small cell lung cancer, pancreatic ductal adenocarcinoma, ovarian cancer, and muscle-invasive bladder cancer. These studies aim to test new cancer therapies, compare treatment strategies, and improve outcomes for patients with advanced or high-risk disease.

  • Evaluation of new options for breast cancer and bladder cancer
  • Comparative studies in pancreatic cancer
  • Research in lung cancer and ovarian cancer to improve effectiveness of care

This oncology portfolio shows a strong interest in both targeted treatment development and better matching of therapy to tumor biology.

Neurology and Sleep Medicine

Trials in nervous system diseases include multiple sclerosis and sleep-related disorders such as narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. The research is focused on reducing symptoms like excessive daytime sleepiness and preventing disease activity, with the goal of improving daily functioning and quality of life.

  • Studies in multiple sclerosis to assess disease control
  • Research on narcolepsy and idiopathic hypersomnia
  • Testing new therapies for excessive daytime sleepiness

These investigations combine neurological and sleep medicine expertise to address conditions that can significantly affect independence and well-being.

Cardiometabolic and Metabolic Disease Research

Another important area is cardiovascular diseases and nutritional and metabolic diseases, including atherosclerotic cardiovascular disease and lipid-related risk. Trials are evaluating whether new therapies can reduce major cardiovascular events while also supporting long-term safety in patients with established disease.

  • Research on atherosclerotic cardiovascular disease and event prevention
  • Studies targeting lipoprotein(a) to lower cardiovascular risk
  • Long-term evaluation of treatment effectiveness in cardiometabolic disease

This work reflects an emphasis on prevention, risk reduction, and better management of chronic heart and metabolic conditions.

Psychiatry and Neuropsychiatric Care

The mental disorders portfolio includes trials in major depressive disorder and related depressive illness, with research aimed at improving symptom relief for people who do not respond fully to current treatment. These studies are testing new therapeutic approaches and examining longer-term tolerability.

  • Clinical research in major depressive disorder
  • Evaluation of add-on treatments for depression
  • Studies focused on improving mental health outcomes

At San Raffaele Scientific Institute, this area adds an important behavioral health dimension to the broader clinical research portfolio.

Metabolic, Immune, and Preventive Research

The site also investigates immune system diseases and preventive strategies in children at increased genetic risk for type 1 diabetes. This research explores whether early vaccination-related approaches can reduce autoimmune risk and improve long-term health protection.

  • Prevention-focused research in children at risk for type 1 diabetes
  • Studies related to autoimmunity and immune protection
  • Clinical work aimed at reducing future metabolic disease burden

These trials show a strong interest in early intervention and disease prevention, extending the site’s research beyond treatment into risk reduction.