Bacterial Infections and Mycoses

The department is investigating bacterial gut infections, aiming to reduce recurrence and improve patient outcomes through innovative antimicrobial and microbiome‑based approaches.

  • Clostridioides difficile infection recurrence prevention strategies
  • Evaluation of novel oral antibiotics
  • Microbiome restoration therapies in post‑infection patients

Research is carried out at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, which currently hosts 29 clinical trials led by 14 investigators.

Cardiovascular Diseases

Studies focus on acute cerebrovascular events, testing thrombolytic agents to extend therapeutic windows and improve functional recovery after stroke.

  • Acute Ischemic Stroke treatment optimization
  • Extended‑window thrombolysis efficacy
  • Long‑term functional outcome assessment

The site’s cardiovascular program is part of the broader effort at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD.

Digestive System Diseases

A robust pipeline of trials addresses inflammatory bowel conditions and gastro‑esophageal disorders, seeking to induce remission and heal mucosal damage.

  • Crohn’s disease induction and maintenance therapies
  • Ulcerative colitis endoscopic response evaluation
  • Erosive esophagitis healing with novel acid suppression agents

Ongoing work is conducted at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, supporting 29 trials across specialties.

Immune System Diseases

The unit explores immune‑modulating treatments for chronic inflammatory disorders, combining biologics with metabolic agents to enhance efficacy.

  • Biologic combination strategies in inflammatory bowel disease
  • Safety profiling of new immune‑targeted antibodies
  • Immune pathway modulation in asthma and related conditions

These investigations are part of the research portfolio of Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD.

Nutritional and Metabolic Diseases

Trials target liver metabolic dysfunction, obesity, and kidney health, evaluating agents that reduce fibrosis, promote weight loss, and slow renal decline.

  • Metabolic Dysfunction‑Associated Steatohepatitis fibrosis regression studies
  • Combination of weight‑loss therapy with IBD treatment
  • Non‑diabetic chronic kidney disease progression delay

The metabolic research program operates at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, contributing to the site’s 29 active trials.

Respiratory Tract Diseases

Focused on asthma management, the department evaluates novel biologics and inhaled therapies to improve lung function and biomarkers of inflammation.

  • Asthma control with anti‑TSLP antibody
  • Exhaled nitric oxide as a pharmacodynamic marker
  • Comparative effectiveness of new inhaled bronchodilators

Research is carried out at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, integrating respiratory studies within its broader clinical trial portfolio.

Virus Diseases

The site conducts antiviral research, particularly in pediatric COVID‑19, to define safe dosing and assess therapeutic benefit in non‑hospitalized patients.

  • SARS‑CoV‑2 Infection pediatric pharmacokinetic modeling
  • Safety and tolerability of oral antiviral regimens in children
  • Dosing optimization to match adult exposure levels

These virus‑focused investigations are part of the work at Multiprofile Hospital For Active Treatment St. Ivan Rilski Gorna Oriahovitsa EOOD, which currently oversees 29 trials.