Clinical trials on Ulcerative keratitis

Overview of Ulcerative Keratitis

Ulcerative keratitis is a serious condition of the eye that involves the cornea, the clear, dome-shaped surface that covers the front of the eye. This condition is characterized by the inflammation and ulceration of the corneal surface, which can lead to significant discomfort, visual impairment, and, if left untreated, can result in severe complications including vision loss. It is often associated with an infectious cause, most commonly bacterial, viral, fungal, or parasitic agents, though non-infectious factors such as dry eye, severe allergic eye disease, and other autoimmune diseases can also contribute to its development.

The symptoms of ulcerative keratitis can vary depending on the underlying cause but typically include severe pain, redness of the eye, blurred vision, sensitivity to light (photophobia), and the sensation of a foreign body in the eye. Diagnosis is primarily based on clinical examination, which may be supplemented with microbiological testing to identify the specific infectious agent involved. Treatment strategies are tailored according to the cause and severity of the condition, with options ranging from antibiotic, antifungal, or antiviral medications for infectious causes, to corticosteroids and immunosuppressive agents for inflammatory causes. In severe cases, surgical intervention such as corneal transplantation may be necessary to restore vision.

Preventive measures are crucial in reducing the risk of developing ulcerative keratitis. These include practicing good contact lens hygiene, protecting the eyes from trauma, and managing underlying conditions that may predispose to the disease. Early detection and prompt treatment are essential to prevent the progression of the disease and preserve vision. Individuals experiencing symptoms of ulcerative keratitis should seek immediate medical attention to ensure the best possible outcome.

Prognosis for Ulcerative Keratitis

Ulcerative keratitis is an inflammatory condition of the eye where ulcers form on the cornea, leading to pain and potential vision impairment. The long-term outlook for ulcerative keratitis largely depends on the severity and cause of the condition, as well as the timeliness and effectiveness of the intervention. If diagnosed early and managed promptly, there is a good prognosis with a possibility of full recovery of vision. However, severe cases, particularly those left untreated or not adequately addressed, may lead to complications such as scarring, thinning of the cornea, or even vision loss. Regular monitoring and follow-up care are crucial to managing the condition effectively and improving long-term visual outcomes. Adherence to medical advice and attendance at all scheduled eye examinations are essential to optimize the prognosis and maintain eye health.

Complications in Ulcerative Keratitis

Ulcerative keratitis can lead to several complications that may significantly impact health and daily life. If the condition progresses, it can cause corneal thinning, making the eye’s protective outer layer weak and more susceptible to injury. In severe cases, a hole, or perforation, may develop in the cornea, which can result in serious infections and possibly vision loss. Scarring is another potential complication, which can blur vision and make clarity difficult. This can interfere with routine activities like reading, driving, or using digital devices. Additionally, chronic inflammation from ulcerative keratitis might lead to the growth of new blood vessels in the cornea, further obstructing vision. These complications can cause discomfort, pain, and sensitivity to light, all of which can diminish the overall quality of life.

Treatment Methods for Ulcerative Keratitis

In managing ulcerative keratitis, the incorporation of lifestyle adjustments alongside medical interventions is considered. Dietary modifications can play a supportive role; the consumption of foods rich in vitamins A and C may promote eye health. Regular physical activity, while not directly treating the eye, contributes to overall well-being, which can aid in recovery.

Pharmacotherapy is often recommended, with medications prescribed tailored to individual needs. Antibiotics or antifungal agents are commonly used to address the underlying infection, while corticosteroids may be prescribed to reduce inflammation.

Modern technology offers additional support. For instance, the use of specialized contact lenses can protect the cornea and facilitate healing. Phototherapeutic keratectomy, a laser treatment, may be suggested to remove affected tissue and improve the corneal surface.

These treatment methods aim to manage symptoms and support the healing process. Following the healthcare provider’s guidance is crucial for optimal outcomes.

  • CT-EU-00088910

    Testing a Wharton’s jelly extracts for chronic keratitis

    This clinical trial investigates the use of a specialized eye drop made of extract of umbilical cord lining constituted of Wharton’s jelly to treat chronic keratitis, an enduring eye condition that often manifests with symptoms like dryness, redness, and eye pain. Since conventional treatments have been ineffective, this study aims to evaluate the efficacy of this novel approach. During the trial, doctors will meticulously monitor these symptoms using a scoring system to assess their frequency and severity. They will also examine the skin around the eyes and monitor any changes in vision. Furthermore, they will employ a special dye called fluorescein to detect alterations in the eye’s surface and evaluate the patients’ visual acuity.

    • Wharton’s jelly extract/SygeLIX-Coll-T