Clinical trials on Short Bowel Syndrome

Overview of Short Bowel Syndrome

Short Bowel Syndrome (SBS), also known as short gut syndrome, is a complex condition that occurs due to the physical loss or the functional absence of a significant portion of the small intestine. This loss impairs the body’s ability to absorb nutrients, vitamins, and minerals from food, leading to a range of nutritional deficiencies and associated health issues. SBS is often a consequence of surgical removal of a large part of the small intestine due to diseases such as Crohn’s disease, ischemia, or congenital defects.

The symptoms and severity of Short Bowel Syndrome can vary widely among individuals, depending on the extent of the small intestine removed and the remaining portion’s health. Common symptoms include diarrhea, malnutrition, dehydration, and weight loss. Management of SBS focuses on nutritional support, which may involve specialized diets, oral rehydration solutions, parenteral or enteral nutrition, and medications to slow down intestinal transit time. In some cases, surgical interventions or intestinal transplantation may be considered as treatment options.

  • Nutritional Support: Tailoring a diet that maximizes nutrient absorption while minimizing symptoms is crucial. This often involves frequent, small meals rich in vitamins and minerals.
  • Medications: Medications can help manage symptoms, improve nutrient absorption, and reduce complications. Examples include anti-diarrheal drugs, proton pump inhibitors, and growth hormones.
  • Surgical Options: In severe cases, surgical interventions such as intestinal lengthening procedures or transplantation may offer hope for improving quality of life.

Living with Short Bowel Syndrome requires ongoing care and adjustments to treatment plans to manage symptoms and prevent complications. With appropriate management, individuals with SBS can lead fulfilling lives, although they may face challenges related to nutrition and digestion.

Prognosis for Short Bowel Syndrome

Short Bowel Syndrome (SBS) is a disorder characterized by the inability of the intestine to absorb nutrients adequately due to its significantly reduced length. The long-term prospects for patients with SBS vary widely and are influenced by the remaining length and condition of the intestine, the specific sections removed, and the overall health of the patient. Management of diet and nutrition, often requiring specialized nutritional support, can enable many patients to lead full lives. Adaptation, where the intestine gradually improves its absorptive capacity, can occur over time, enhancing the prognosis. However, severe malnutrition may be experienced by some and could necessitate long-term parenteral nutrition or an intestinal transplant. The prognosis is generally better for those who retain a larger portion of the small intestine, particularly if the ileocecal valve is intact. Lifelong follow-up with a healthcare team specialized in SBS is crucial for monitoring and managing the condition to optimize health outcomes and quality of life.

Complications in Short Bowel Syndrome

Short Bowel Syndrome (SBS) can lead to various complications that affect health and daily living. A major issue is malnutrition, as the body struggles to absorb enough nutrients. This can result in weight loss, weakness, and fatigue, making everyday tasks challenging. There may also be experiences of dehydration due to difficulty in retaining water, which can cause headaches and dizziness. Frequent diarrhea is another common complication, potentially leading to embarrassment and limiting social activities. Additionally, SBS can cause an imbalance of electrolytes—vital minerals in the body—increasing the risk of heart problems and muscle issues. Bone health can suffer as well, with a higher chance of fractures. Lastly, the risk of kidney stones is elevated, which can cause significant discomfort. These complications can severely impact the quality of life, making it hard to enjoy activities and maintain a normal routine.

Revolutionizing Short Bowel Syndrome Management

For Short Bowel Syndrome, the embrace of a tailored diet is crucial. This involves the inclusion of nutrient-rich foods, smaller, frequent meals, and specific vitamin supplements. Hydration is key; oral rehydration solutions may be recommended. Physical activity, tailored to individual tolerance, supports overall health and digestion.

Pharmacotherapy options include medications that slow intestinal movement, enhance nutrient absorption, and reduce gastric acid. Certain patients may benefit from specific growth hormones or anti-diarrheal drugs to improve nutrient uptake.

Modern technology offers innovative solutions. Enteral nutrition pumps deliver nutrients directly to the digestive tract, while parenteral nutrition provides them intravenously, bypassing the gut entirely when necessary. Apps and wearable devices can assist in tracking nutritional intake, hydration levels, and physical activity, ensuring a comprehensive approach to managing Short Bowel Syndrome.

  • CT-EU-00084495

    Evaluation of oral antibiotic absorption in short bowel syndrome patients

    This research is carried out to see how well tablets or liquid antibiotics are taken in by the body for individuals with short bowel syndrome, a condition where there is a shorter than usual intestine. If patients have an infection, these individuals are given one of these antibiotics: Amoxicillin, Levofloxacin, Ofloxacin or Sulfamethoxazole trimethoprim through a drip. Scientists will look at how the medication moves through the body with this method. Once this stage is complete, the same antibiotic that was previously given intravenously is given by mouth, and similarly observed. The results from both situations are then compared to see how well the oral medicine is absorbed by the body. The study also looks at the peak level of the antibiotic in the blood after oral intake, the time it takes to reach that peak. The length of the remaining intestine is also observed.

    • Amoxicillin
    • Levofloxacin
    • Ofloxacin
    • Sulfamethoxazole trimethoprim
  • Long-term safety study of Apraglutide for Short Bowel Syndrome

    The purpose of this study is to investigate the impact of a specific medication, apraglutide, on individuals with Short Bowel Syndrome, a condition often caused by the absence or malfunction of a portion of the small intestine, leading to challenges in nutrient and fluid absorption. The study includes individuals who participated in either the TA799-007 or TA799-013 trials. Participants in this study will receive apraglutide once a week for a duration of 208 weeks or until apraglutide becomes commercially available. The research aims to assess various factors such as weight, caloric intake, blood pressure, and heart rate to identify any significant changes associated with the medication.

    • Apraglutide
  • Study on new medicine’s effect and safety in short bowel syndrome treatment

    This trial is designed to check how safe and effective a drug named HM15912 is for people suffering from severe bowel problems, a condition known as short bowel syndrome (SBS). Some patients will get the real drug, while others get placebo – and nobody will know who will get what. The doctors then will check how these injections of HM15912 impact your health, how your body processes the drug, and how the drug affects your body’s functions. The entire process will extend over a period of about 13 months, along with a safety follow-up period.

    • HM15912
  • Evaluating the long-term effects of glepaglutide on Short Bowel Syndrome

    The study focuses on glepaglutide’s long-term safety and effectiveness in treating Short Bowel Syndrome (SBS). It examines how different doses, given weekly, help manage SBS, aiming to enhance the quality of life and reduce dependence on parenteral support. The study is pivotal in offering sustainable treatment options for SBS patients.

    • glepaglutide