Clinical trials on Secondary Adrenal Insufficiency

Secondary adrenal insufficiency occurs when the pituitary gland in the brain does not secrete enough adrenocorticotropic hormone (ACTH), which is crucial for stimulating the adrenal glands to produce cortisol. Without adequate ACTH, cortisol production drops, leading to various symptoms and disturbances in the body. Complications of Secondary Adrenal Insufficiency include:
  1. Chronic Fatigue: Due to cortisol’s role in energy regulation.
  2. Muscle Weakness: Lack of cortisol can lead to a general feeling of weakness.
  3. Gastrointestinal Issues: Including appetite loss and abdominal pain.
  4. Mood Swings and Depression: Cortisol is involved in mood regulation.
  5. Susceptibility to Infections: Cortisol has anti-inflammatory actions and influences the immune response.
Therapies for Secondary Adrenal Insufficiency involve:
  1. Hydrocortisone Therapy: The most common form of treatment which replaces cortisol.
  2. Prednisone or Dexamethasone: Other forms of corticosteroids that may be used less frequently due to longer half-life and increased risk of side effects.
  3. Fludrocortisone Acetate: May be needed if the body’s aldosterone production is insufficient.
  4. Adjustment of Medication: Particularly during periods of stress, surgery, or illness when the body would naturally produce more cortisol.
  5. Education on Emergency Injection: Patients are often taught how to self-administer an emergency hydrocortisone injection in case of an adrenal crisis.
Prognosis of Secondary Adrenal Insufficiency: The long-term outlook for patients with secondary adrenal insufficiency is generally good if they receive proper treatment and adhere to their medication regimen. Continuous treatment and regular follow-ups with a healthcare provider are essential. Patients should be aware of the signs of adrenal crisis and the necessity of medication adjustment during illness or stress. With these measures, individuals with secondary adrenal insufficiency typically lead active, healthy lives. However, undiagnosed or untreated, the condition can lead to serious health issues, so prompt and ongoing medical care is critical.
  • CT-EU-00112175

    A non-invasive test to assess adrenal function in children with asthma using inhaled steroids

    The study is focused on developing a new way to check whether the body is producing enough of an essential stress hormone called cortisol, especially in children using inhaled steroids to treat asthma. Steroid inhalers are common, but there is concern that they may prevent the body from producing enough cortisol when it is really needed, such as during illness. This could be serious. Currently, doctors use a test called the short synacten test (SST) to check whether the adrenal glands (which produce cortisol) are functioning properly. But this test requires needles and can be stressful and unpleasant, especially for children.

    The goal of the study is to create a non-invasive version of this test. Instead of needles, doctors want to use a nasal spray of a drug called Synacthen, which stimulates the adrenal glands, and then measure cortisol levels in saliva. This new method could make testing easier, faster and more convenient for children.

    Doctors will start by testing this new approach in adults to understand how well it works and how it compares to the traditional test. They will look at how the body absorbs the drug and how it affects cortisol levels. They will then perform the same tests on children to make sure it is safe and effective for them too.

    • nasal Tetracosactide
    • IV tetracosactide