Clinical trials on Rhegmatogenous Retinal Detachments

  • CT-EU-00111363

    Exploring the Impact of Retinal Detachment on Eye Molecular Composition

    We are conducting a study titled “Study of Vitreoretinal Molecular Changes During Rhegmatogenous Retinal Detachment” to explore the changes that occur in the eye when it experiences a condition known as retinal detachment. This condition affects a small number of people but can seriously threaten one’s ability to see if not treated promptly. Despite successful surgeries to fix the detached retina, some patients still face issues due to the death of certain eye cells and other complications, which are not fully understood.

    Our research is particularly focused on the vitreous humour, a gel-like substance inside the eye, and how its composition changes in those with retinal detachment compared to those undergoing eye surgery for other reasons. We suspect that the levels of certain fats, known as omega-3 PUFAs, and proteins in the vitreous humour are different in patients with retinal detachment. These differences could be linked to inflammation inside the eye and the death of photoreceptor cells, which are crucial for capturing visual information.

    To investigate this, we will be collecting samples from patients undergoing surgery for retinal detachment at the Ophthalmology Department of the Dijon University Hospital. We will compare these samples to those from patients having surgery for other macular issues, like epiretinal membrane or macular hole, to see if there are noticeable differences in the molecular content of their vitreous humour.

    Additionally, we aim to see if the levels of omega-3 PUFAs in the retina can influence the recovery process after retinal detachment surgery. We are also interested in finding a blood marker that could help predict the outcome of retinal detachment, which could be a significant step forward in treating this condition.

    Participants in this study will have their clinical details recorded, including any history of dyslipidaemia (a condition with abnormal amounts of lipids in the blood) and their current treatments. We will also follow up with patients for six months after surgery to monitor their recovery.

    This study could help us understand the molecular changes that occur during retinal detachment and lead to new treatments that improve the visual outcomes for patients facing this challenging condition.