Clinical trials on Kidney failure

Kidney Failure Overview

Kidney failure, also known as renal failure, is a medical condition where the kidneys lose their ability to sufficiently filter waste products and excess fluids from the blood. This dysfunction can accumulate harmful levels of waste materials in the body, leading to a potentially life-threatening situation. Kidney failure can be categorized into two main types: acute kidney injury (AKI), which develops rapidly over a few hours or days, and chronic kidney disease (CKD), which progresses slowly over months or years.

The causes of kidney failure are varied and can include factors such as diabetes, high blood pressure, chronic glomerulonephritis, polycystic kidney disease, and prolonged obstruction of the urinary tract. Symptoms of kidney failure are often non-specific and can include fatigue, reduced appetite, swelling in the feet and ankles, and changes in urine output. Due to the insidious nature of its symptoms, kidney failure is frequently diagnosed through blood and urine tests that are conducted for other reasons.

  • Diagnosis and Treatment: Diagnosing kidney failure involves a combination of blood tests, urine tests, imaging studies, and sometimes a kidney biopsy. Treatment focuses on addressing the underlying cause of the failure, managing symptoms, and preventing complications. In cases of advanced kidney failure, dialysis or kidney transplantation may be necessary.
  • Prevention: Preventive measures include maintaining a healthy lifestyle, controlling blood pressure and diabetes, and regular monitoring for those at risk of kidney disease. Early detection and treatment of conditions that can lead to kidney failure are crucial in preventing the progression of the disease.

Understanding the causes and symptoms of kidney failure is essential for early detection and treatment. With appropriate medical intervention, individuals with kidney failure can manage their condition and lead fulfilling lives.

Prognosis for Kidney Failure

Kidney failure, also known as renal failure, is a condition where the kidneys lose their ability to filter waste and excess fluids from the blood effectively. The long-term prospects for individuals with kidney failure vary widely and are influenced by the stage of the disease at diagnosis, the underlying cause, and the individual’s overall health. In early stages, the progression of kidney failure can often be slowed with appropriate management, but as the disease advances, the damage to the kidneys may become irreversible, necessitating dialysis or a kidney transplant for long-term survival. The prognosis is generally more favorable for those who are able to receive a transplant and have a good match. However, without treatment, end-stage kidney failure is life-threatening. The quality of life can be maintained with proper medical care, and many individuals live active lives, although the condition requires ongoing management to monitor and address any complications that arise.

Complications in Kidney Failure

When kidneys fail, they can no longer filter waste effectively, leading to a buildup of toxins in the body. This can cause a range of complications that significantly impact health and daily living. High blood pressure is a common issue, as the kidneys help regulate blood pressure. Anemia may develop because kidneys also play a role in red blood cell production. Fluid retention can cause swelling in the legs, ankles, or feet, and may lead to fluid in the lungs, making breathing difficult. Electrolyte imbalances, particularly of potassium and phosphorus, can affect heart and muscle function. Additionally, kidney failure can lead to weakened bones and an increased risk of fractures. There may be fatigue, difficulty concentrating, and a reduced appetite, which can affect overall quality of life. These complications underscore the critical role kidneys play in maintaining overall health.

Revitalization of Kidneys: Embracing a Healthier Lifestyle

In the management of kidney failure, the adoption of a balanced diet is crucial. This involves the reduction of sodium, potassium, and phosphorus intake to ease the strain on the kidneys. Emphasis on fresh fruits, vegetables, and whole grains, while limiting processed foods, supports kidney health. Regular physical activity, tailored to the individual’s capacity, promotes overall well-being and aids in the management of blood pressure and weight.

Pharmacotherapy options, though not in clinical trials, may be recommended to address specific needs. These can include medications to control blood pressure, manage anemia, or balance electrolytes, always under medical supervision.

Modern technology offers innovative tools for the monitoring of health. Wearable devices can track vital signs, while mobile apps assist in the management of medication schedules and diet. Home blood pressure monitors and digital scales help individuals stay informed about their health status.

Incorporating these lifestyle adjustments, pharmacotherapy, and technological aids can significantly contribute to the management of kidney failure, enhancing the quality of life and supporting kidney function.

  • CT-EU-00057257

    Study of the effect of a new drug on renal disease with proteinuria

    This study focuses on the investigation of a new drug called Inaxaplin (VX-147), which is being tested in people with apolipoprotein L1 (APOL1)-dependent proteinuria kidney disease. The study took a comparative approach, with one group receiving the actual drug and the other receiving a placebo. The main objectives include assessing the effectiveness of Inaxaplin and ensuring its safety profile for consumption. The study involves assessing the physiological processing of the drug in the body, and the study population includes both adults and children.

    • Inaxaplin/VX-147
  • Comparison of the effectiveness of two drugs in organ transplantation

    This study is looking at a solution called Custodiol-N that is used to keep organs safe while they are being moved for a transplant operation. It will be compared to the usual solution called Custodiol. The study is checking if this new solution is as good, or better, at protecting the organs. The organs that are being studied are the kidney, liver, and pancreas. It’ll take about 3 months to complete the study with each person. Doctors would check on patients for 90 days after the operation to see how they’re recovering. The study will be run in several centers and should finish after roughly 30 months.

    • Custodiol-N Solution
    • Custodiol HTK Solution