Clinical trials on Hyperandrogenism

  • CT-EU-00114534

    Comparing Acupuncture and Metformin with Lifestyle Changes for PCOS and Insulin Resistance

    This clinical trial is designed to explore the effectiveness of two different treatments for women with Polycystic Ovary Syndrome (PCOS) who are also experiencing insulin resistance. The study aims to compare the impact of combining lifestyle management with either acupuncture or metformin (a medication), against the effects of lifestyle management alone. The main goal is to see how these treatments can improve the body’s ability to manage glucose, which is crucial in preventing the development of type 2 diabetes.

    The trial will last for 4 months, during which the researchers will closely monitor changes in insulin sensitivity, glucose regulation, and overall health markers including hormone levels, body fat distribution, and mental health aspects such as anxiety and depression. One of the unique aspects of this study is its focus on not just the physical health outcomes, but also on the quality of life and emotional well-being of the participants.

    For those considering the metformin treatment, it’s important to note that the medication will be gradually introduced to minimize side effects, starting with a lower dose and increasing to the target dose over the first three weeks. The study also places a strong emphasis on the potential benefits of acupuncture, hypothesizing that it could be equally effective as metformin but with fewer negative side effects.

    This trial is particularly significant for women with PCOS and insulin resistance, as it seeks to provide evidence-based insights into managing these conditions, improving fertility, and potentially preventing the onset of more serious health issues down the line.

    • metformin
  • Understanding Female Metabolic Health: The FEMAIL Study on Androgens and Risk of Diabetes

    The FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study is a research project focused on understanding how certain hormones, known as androgens, affect women’s health, particularly in relation to metabolic diseases like diabetes. Androgens are typically considered male hormones, but they also play a significant role in women’s bodies. This study is particularly interested in a new class of androgens called 11-oxygenated androgens, which have been found to be the main type of androgens in women, including those with a condition called polycystic ovary syndrome (PCOS). PCOS affects about 10% of women and is linked to higher levels of androgens and a risk of developing diabetes.

    The study aims to explore how these 11-oxygenated androgens, especially one called 11-ketotestosterone (11KT), relate to the risk of developing type 2 diabetes and other metabolic issues. Unlike other androgens, 11-oxygenated androgens do not decrease with age, which could mean they influence the risk of diabetes in women throughout their lives.

    Participants in the study will undergo a thorough health assessment, including a questionnaire about their medical history and lifestyle, measurements of their body composition, and tests of their blood, urine, and saliva. These tests will help the researchers understand the participants’ hormone levels, metabolic health, and overall well-being. The study will also include a muscle biopsy, a procedure to collect a small sample of muscle tissue, to get a closer look at how these hormones affect muscle and metabolic health.

    The FEMAIL Study is being conducted by a team of researchers in Ireland and is looking for participants through local advertising in Beaumont Hospital and RCSI Medical School. This research could lead to better understanding of how androgens affect women’s risk of metabolic diseases and potentially uncover new ways to predict and prevent these conditions.

    If you’re interested in learning more about your metabolic health and contributing to important research that could benefit women’s health in the future, this study might be a great opportunity.