Clinical trials on Healthy Female

  • CT-EU-00111434

    Exploring the Impact of Anti-Estrogen Therapy on Brain and Psychosexual Health in Breast Cancer Patients

    This study is focused on understanding how anti-estrogenic therapy, a treatment for breast cancer, affects the brain, psychosexual health, and overall quality of life in women. The researchers are particularly interested in comparing the effects of this therapy in women who are premenopausal (still having menstrual cycles) and postmenopausal (menstrual cycles have stopped), including those who have and haven’t used hormonal replacement therapy. To do this, they are looking at four different groups: premenopausal women with breast cancer on anti-estrogenic therapy, postmenopausal women with breast cancer on anti-estrogenic therapy, premenopausal healthy women, and postmenopausal healthy women.

    Participants in the study will first go through an interview and complete online surveys to share information about their mental health, personality, relationships, and sexual health. For those diagnosed with breast cancer, the study involves two MRI scans: one before starting anti-estrogenic therapy and another two to three weeks after starting the therapy but before any surgery. These scans will help the researchers look at the structure and function of the brain, including how it processes rewards, which can be linked to motivation and pleasure. Healthy participants will go through a similar process for comparison.

    The medications used in this study for breast cancer patients include Tamoxifen and Letrozole, with some receiving Letrozole in combination with a GnRH injection. These treatments will be given for two to three weeks.

    The main goal is to see how anti-estrogenic therapy might change the brain and affect how women feel and function, especially in terms of their psychosexual health and quality of life. This research is important because it can help improve the support and treatments given to women with breast cancer, making sure they not only survive but also maintain a good quality of life during and after treatment.

    • Letrozole + GnRH
    • Letrozole
    • tamoxifen