Clinical trials on Diabetic Neuropathy

Understanding Diabetic Neuropathy

Diabetic neuropathy represents a group of nerve disorders caused by diabetes. Over time, high blood sugar levels from diabetes can damage the nerves throughout the body, but diabetic neuropathy most often damages nerves in the legs and feet. Depending on the affected nerves, symptoms can range from pain and numbness in the extremities to problems with the digestive system, urinary tract, blood vessels, and heart. For some people, these symptoms are mild; for others, diabetic neuropathy can be painful, disabling, and even fatal.

Symptoms and Types

There are several types of diabetic neuropathy, each with its unique set of symptoms. Peripheral neuropathy is the most common form, typically affecting the feet and legs first, followed by the hands and arms. Symptoms may include numbness, reduced ability to feel pain or temperature changes, sharp pains or cramps, and increased sensitivity to touch. Autonomic neuropathy affects the autonomic nerves controlling the heart, bladder, stomach, intestines, sex organs, and eyes, leading to a variety of symptoms, including digestive issues, urinary problems, sexual dysfunction, and changes in blood pressure. Proximal neuropathy and focal neuropathy are less common and can lead to muscle weakness and pain in specific areas of the body.

Prevention and Management

Managing blood sugar levels is crucial in preventing or delaying the onset of diabetic neuropathy and in reducing symptoms for those already affected. A comprehensive management plan includes regular monitoring of blood glucose levels, a healthy diet, regular physical activity, and, if necessary, medication. Additionally, regular foot care and examination can prevent complications from peripheral neuropathy. Early diagnosis and treatment offer the best chance for controlling symptoms and preventing further damage to the nerves.

Prognosis for Diabetic Neuropathy

Diabetic neuropathy is a nerve-damaging disorder associated with diabetes mellitus. The long-term prospects for individuals with diabetic neuropathy vary widely and are largely dependent on the management of blood sugar levels. Early diagnosis and strict blood sugar control can often prevent or slow the progression of diabetic neuropathy. Over time, however, even with good glycemic management, some individuals may experience symptoms ranging from pain and numbness in the extremities to problems with the digestive system, urinary tract, blood vessels, and heart. Some forms of diabetic neuropathy can lead to severe complications, including limb amputation due to infection or lack of blood flow. The rate of progression and the severity of symptoms can differ, with some maintaining a good quality of life and others experiencing significant disability. It is crucial to monitor and manage the condition effectively in collaboration with healthcare providers.

Complications in Diabetic Neuropathy

Diabetic neuropathy may lead to several complications that significantly impact daily life. Nerve damage primarily causes loss of sensation in the feet, making it difficult to detect injuries or infections. This numbness can result in unnoticed wounds that may develop into serious infections. Additionally, there might be experiences of sharp pains or cramps, complicating the performance of everyday tasks. Digestive issues, such as nausea, vomiting, and diarrhea, can also arise, disrupting normal eating patterns and nutrition. In some instances, diabetic neuropathy affects the heart, leading to changes in blood pressure that can cause dizziness or fainting. Moreover, the condition can impair bladder function, leading to urinary tract infections or incontinence. These complications can reduce quality of life, as they may limit mobility, lead to chronic discomfort, and increase the risk of further health issues.

Treatment Methods for Diabetic Neuropathy

For the management of diabetic neuropathy, lifestyle modifications are crucial. A balanced diet rich in nutrients supports nerve health, while regular physical activity improves blood circulation. Pharmacotherapy may include medications to alleviate pain and discomfort. Modern technology offers options like transcutaneous electrical nerve stimulation (TENS), which uses mild electrical currents for pain relief. Consulting healthcare providers is important to tailor treatments to individual needs.

  • CT-EU-00084757

    Investigating diabetic foot pain treatment with incobotulinumtoxin-A

    This clinical trial is for people with diabetes who often suffer from nerve pains in their feet and lower legs. Here special injections will be used around the offending nerve, to see if these can provide relief and be safe. The injections contain either incobotulinumtoxin-A, a medicine thought to help, or a placebo, which is inactive. Doctors will check how the pain affects life, mood, daily activities, and the basic sensation in feet and lower legs. A safe procedure will guide all injections, and it involves the use of an ultrasound and a non-cutting needle, to ensure the right placement. The trial will record any side effects and changes in muscular and sensual functions.

    • Incobotulinumtoxin-A
  • Assessing new drug impact on chronic diabetic peripheral neuropathic pain

    This study focuses on testing a new medicine called GSK3858279 for people living with chronic Diabetic Peripheral Neuropathic Pain that’s not been well-managed. The medicine will be given to some people selected at random, while others will receive a placebo. It’s important that neither the patient nor the doctors will know who received the drug and who got the placebo. The main aim is to check how well GSK3858279 works for nerve pain. Participants will keep track of their pain daily using a simple scale from 0 (no pain) to 10 (worst imaginable pain). These daily scores will then be added up each week. Additionally, any health issues occurring during the study will be closely monitored, regardless of their relation to GSK3858279.

    • GSK3858279- new potential medication for chronic pain associated with osteoarthritis